Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults.

Autor: Okumura K; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.; Department of Epidemiology, Nara Medical University School of Medicine, Kashihara, Japan., Takeda T; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan., Komori T; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Toritsuka M; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan., Yamamuro K; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Takada R; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Ikehara M; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Kamikawa K; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Noriyama Y; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Nishi Y; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Ishida R; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan., Kayashima Y; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Yamauchi T; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan., Iwata N; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan., Makinodan M; Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.; Osaka Psychiatric Research Center, Osaka, Japan.
Jazyk: angličtina
Zdroj: Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2024 Oct; Vol. 78 (10), pp. 580-587. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1111/pcn.13712
Abstrakt: Aim: Adverse childhood experiences are potentially traumatic events with long-lasting effects on the health and well-being of patients with autism spectrum disorder (ASD). It is important to clarify which types of long-lasting autism-related symptoms are influenced by childhood experiences to design future intervention studies. However, few studies have examined the association between childhood experiences and autistic symptoms in large samples of adults with ASD and individuals with typical development (TD). In this study, we evaluate the effects of adverse childhood experiences on multiple ASD phenotypes among both individuals with ASD and those with TD.
Method: We combined questionnaire evaluations; Childhood Abuse and Trauma Scale, the Japanese version of the Autism-Spectrum Quotient, Conners' Adult ADHD Rating Scale, the Japanese version of the Impact of Event Scale-Revised, and the Japanese version of the Adolescent/Adult Sensory Profile.
Results: Individuals with ASD and those with TD (n = 205 and 104, respectively) were included. There were significant correlations between the extent of adverse childhood experiences and severity of attention-deficit/hyperactivity disorder symptoms, posttraumatic stress disorder symptoms, and hypersensitivity in both participants with ASD and those with TD. By contrast, ASD core symptoms showed no significant correlation with adverse childhood experiences in either group. These results remained consistent after adjusting for age, sex, and the estimated intelligence quotient.
Conclusion: These findings suggest the need for a detailed disentanglement of ASD-related core and peripheral symptoms of adverse childhood experiences, which may help to appropriately set outcomes for future early interventions for the childhood experiences of individuals with ASD.
(© 2024 The Author(s). Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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