| Autor: |
Gao K; Department of VIP Dental Service, Capital Medical University School of Stomatology, Beijing 100050, China., Wei XZ; Department of Emergency and General Dentistry, Capital Medical University School of Stomatology, Beijing 100050, China., Zhao B; Department of Pharmacy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China., Liu ZG; Statistics Department, Pharmacology Base, Beijing Anzhen Hospital, Capital Medical University, Beijing 100011, China., Du CL; Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China., Wang X; Department of VIP Dental Service, Capital Medical University School of Stomatology, Beijing 100050, China., Wang Y; Department of Implantology, Capital Medical University School of Stomatology, Beijing 100050, China., Liu CY; Department of Implantology, Capital Medical University School of Stomatology, Beijing 100050, China., Tang DZ; Department of Implantology, Capital Medical University School of Stomatology, Beijing 100050, China., Zhang Q; Department of Stomatology, Beijing TianTan Hospital, Capital Medical University, Beijing 100070, China., Wu RQ; Department of Stomatology, Beijing TianTan Hospital, Capital Medical University, Beijing 100070, China., Ou MM; Department of Stomatology, Beijing TianTan Hospital, Capital Medical University, Beijing 100070, China., Li W; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Cheng Q; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Xie YL; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Ma P; Department of Implantology, Capital Medical University School of Stomatology, Beijing 100050, China., Li J; Department of Implantology, Capital Medical University School of Stomatology, Beijing 100050, China., Wang H; Department of Stomatology, Beijing TianTan Hospital, Capital Medical University, Beijing 100070, China., Wang ZM; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Chen S; Department of VIP Dental Service, Capital Medical University School of Stomatology, Beijing 100050, China., Zhang W; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China., Zhou J; Department of VIP Dental Service, Capital Medical University School of Stomatology, Beijing 100050, China. |
| Abstrakt: |
Objective: To evaluate the effect of preemptive analgesia with ibuprofen on postoperative pain following single posterior tooth implantation, aiming to provide a clinical reference for its application. Methods: A multicenter, randomized, double-blind, placebo-controlled parallel-group trial was conducted. A total of 82 participants were included in the trial, meeting the eligibility criteria from April 2022 to April 2024 at the Capital Medical University School of Stomatology (40 cases), Beijing TianTan Hospital, Capital Medical University (22 cases), Beijing Chao-Yang Hospital, Capital Medical University (20 cases). Participants were randomly assigned in a 1∶1 ratio to either the ibuprofen group or the control group, with each group comprising 41 individuals. Participants in the ibuprofen group received 300 mg of sustained-release ibuprofen capsules orally 15 min before surgery, while the control group received a placebo. Both groups received the same postoperative analgesic regimen for 3 days. Pain scores were assessed using the Numerical rating scale (NRS) at 30 min, 4 h, 6 h, 8 h, 24 h, 48 h, and 72 h postoperatively, and the additional use of analgesic medication was recorded from days 4 to 6 postoperatively. Results: A total of 82 participants were initially enrolled in the study, with 7 dropouts (4 from the control group and 3 from the ibuprofen group), resulting in 75 participants (37 in the control group and 38 in the ibuprofen group) completing the trial. There were no reports of adverse events such as nausea or vomiting among the participants. The ibuprofen group exhibited significantly lower pain scores at 4 h, 6 h and 8 h [1.0 (0.0, 2.0), 1.0 (0.0, 2.0), 1.5 (0.0, 3.0) ] postoperatively compared to the control group 4 h, 6 h and 8 h [2.0 (1.0, 3.0), 3.0 (1.5, 4.0), 2.0 (1.0, 4.0)] ( Z =-1.99, P =0.047; Z =-3.01, P =0.003; Z =2.10, P =0.036). The proportions of patients requiring additional analgesic medication between days 4 and 6 post-surgery were 18.4% (7/38) in the ibuprofen group and 27.0% (10/37) in the control group, with no significant difference (χ 2 =0.79, P =0.373). The median additional medication usage postoperatively was [0.0 (0.0, 0.0) pills] in the ibuprofen group and [0.0 (0.0, 1.0) pills] in the control group, with no significant difference ( Z =-0.78, P =0.439). Conclusions: Preemptive analgesia with ibuprofen effectively reduces postoperative pain following tooth implantation, representing a safe and effective perioperative pain management strategy. |
