PV and SST neurons in the anterior cingulate cortex regulate social disorders in adulthood induced by sensory abnormalities in childhood.

Autor: Wan XD; The Key Laboratory of Neural and Vascular Biology, Ministry of Education and Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China.; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., Cai GH; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Yan ZQ; Graduate School of Hebei Medical University, Shijiazhuang, China., Liu XQ; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., Yang DD; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., Lu YF; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., An LT; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., Wu SX; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China., Zhang F; The Key Laboratory of Neural and Vascular Biology, Ministry of Education and Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China.
Jazyk: angličtina
Zdroj: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Jul; Vol. 30 (7), pp. e14863.
DOI: 10.1111/cns.14863
Abstrakt: Objective: Childhood sensory abnormalities experience has a crucial influence on the structure and function of the adult brain. The underlying mechanism of neurological function induced by childhood sensory abnormalities experience is still unclear. Our study was to investigate whether the GABAergic neurons in the anterior cingulate cortex (ACC) regulate social disorders caused by childhood sensory abnormalities experience.
Methods: We used two mouse models, complete Freund's adjuvant (CFA) injection mice and bilateral whisker trimming (BWT) mice in childhood. We applied immunofluorescence, chemogenetic and optogenetic to study the mechanism of parvalbumin (PV) neurons and somatostatin (SST) neurons in ACC in regulating social disorders induced by sensory abnormalities in childhood.
Results: Inflammatory pain in childhood leads to social preference disorders, while BWT in childhood leads to social novelty disorders in adult mice. Inflammatory pain and BWT in childhood caused an increase in the number of PV and SST neurons, respectively, in adult mice ACC. Inhibiting PV neurons in ACC improved social preference disorders in adult mice that experienced inflammatory pain during childhood. Inhibiting SST neurons in ACC improved social novelty disorders in adult mice that experienced BWT in childhood.
Conclusions: Our study reveals that PV and SST neurons of the ACC may play a critical role in regulating social disorders induced by sensory abnormalities in childhood.
(© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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