A Rare Case Report of Hypoketotic Hypoglycemia Induced Seizures Due to Secondary Carnitine Deficiency in a 44-year-old Female.

Autor:	Bangolo A; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Tesoro N; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Onyeka S; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Bangura M; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Shrestha R; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Nagesh VK; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Alrestom R; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Rathod J; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Gomez EL; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Laabidi Y; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Laabidi I; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Erikson C; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Sheikh A; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Maria S; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Naria M; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Tabucanon EJ; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Dongre JV; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Auda A; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Jurri M; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Radhakrishnan R; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA., Alrefai H; Department of Endocrinology, Endocrines Associates, Louisville, KY, USA., Weissman S; Department of Medicine, Palisades Medical Center, North Bergen, NJ, USA.
Jazyk:	angličtina
Zdroj:	Journal of community hospital internal medicine perspectives [J Community Hosp Intern Med Perspect] 2024 May 07; Vol. 14 (3), pp. 68-71. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
DOI:	10.55729/2000-9666.1279
Abstrakt:	Carnitine deficiency is a rare metabolic condition that can result in fasting hypoglycemia. Carnitine deficiency could be primary or secondary to other conditions. Among secondary causes, antiepileptics such as valproic acid have been incriminated. Valproic acid is known to deplete carnitine stores and inhibit the process of β-oxidation. Herein we report the case of a 44-year-old female with epilepsy that presented with breakthrough seizures associated with hypoglycemia despite being on appropriate antiepileptic therapy. The patient was later found to have carnitine deficiency. Discontinuation of valproic acid and supplementation with l-carnitine resolved the patient's hypoglycemia and breakthrough seizures. With this case report, we hope to encourage clinicians to include carnitine deficiency in the differential diagnosis of unexplained hypoglycemia. Competing Interests: Conflicts of interest: No potential conflict of interest was reported by the authors. (© 2024 Greater Baltimore Medical Center.)
Databáze:	MEDLINE
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