An Uncommon Association: HLA-B27 Positivity in Conjunction With Pernicious Anemia - A Case Report and Literature Review.

Autor:	Auda AH; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Atoot R; Internal Medicine, Englewood Hospital, Englewood, USA., Jurri M; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Mahmoud A; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Siddiqui A; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Bangolo A; Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Malik T; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Baker I; Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA., Sotiriadis J; Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.
Jazyk:	angličtina
Zdroj:	Journal of community hospital internal medicine perspectives [J Community Hosp Intern Med Perspect] 2024 May 07; Vol. 14 (3), pp. 49-50. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
DOI:	10.55729/2000-9666.1340
Abstrakt:	Pernicious anemia, stemming from Vitamin B12 deficiency and autoimmune processes affecting intrinsic factor production, presents challenges in early diagnosis due to vague initial symptoms. This case report introduces a unique occurrence of pernicious anemia-induced peripheral neuropathy in a patient with concurrent HLA-B27 arthropathy, highlighting the complex interplay of autoimmune mechanisms. While HLA-B27 is not typically associated with pernicious anemia, the case underscores the importance of exploring specific HLA haplotypes in understanding the nuanced manifestation of autoimmune disorders. Comprehensive screening for anti-intrinsic factor and anti-parietal cell antibodies is crucial in individuals with signs of pernicious anemia, especially those with a history of HLA-B27 arthropathy, guiding tailored management strategies. This report contributes to the ongoing exploration of the intricate autoimmune landscape in pernicious anemia. Competing Interests: Conflict of interest: No conflicts of interest to declare. (© 2024 Greater Baltimore Medical Center.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu