Corticosteroid administration and glycemic outcomes during treatment of acute exacerbation of chronic obstructive pulmonary disease.
| Autor: | Johannesmeyer HJ; Assistant Professor of Pharmacy Practice, Marshall B. Ketchum University, College of Pharmacy, 2575 Yorba Linda Blvd., Fullerton, CA 92831, United States., Moussavi K; Assistant Professor of Pharmacy Practice, Marshall B. Ketchum University, College of Pharmacy, United States., Rambaran KA; Emergency Medicine Pharmacy Specialist, Scripps Mercy Hospital San Diego, United States., Kolyouthapong K; Medication Safety Pharmacist, Mission Hospital - Mission Viejo, United States. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of medicine open [Am J Med Open] 2022 Nov 07; Vol. 8, pp. 100027. Date of Electronic Publication: 2022 Nov 07 (Print Publication: 2022). |
| DOI: | 10.1016/j.ajmo.2022.100027 |
| Abstrakt: | Background: While international guidelines recommend low doses of systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) clinical practice patterns show significant heterogeneity. Increasing doses of corticosteroids have inconsistently been associated with a greater risk of hyperglycemia. Methods: Patients admitted to inpatient services for AECOPD were retrospectively enrolled. Hospitalization corticosteroid doses, daily blood glucose levels, and other markers of corticosteroid excess were collected. Correlative and regression analyses were conducted to assess the relationship between corticosteroid dose and average hospitalization blood glucose. Results: Daily corticosteroid dose significantly predicted a higher blood glucose (rs=0.179, p=0.0095; p<0.0028 respectively) and cumulative corticosteroid dose predicted a longer hospital length of stay in bivariate and multivariate analyses (rs=0.679, p<0.0001; p<0.0001 respectively). Patients that experienced hypernatremia, hypokalemia, acute hyperglycemia, and acute hypertension received larger corticosteroid doses than patients that did not experience these complicating events. Conclusions: We identified that increasing amounts of corticosteroids administered to inpatients experiencing AECOPD experienced higher average hospitalization blood glucose values, protracted hospitalizations, and other untoward effects. Competing Interests: All authors declare no financial conflicts of interest. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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