[Clinical, aetiological and therapeutic features of severe sickle cell related vaso-occlusive crisis at the Sylvanus Olympio University Hospital, Lomé].

Autor: Guedenon KM; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Akolly DAE; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Fiawoo M; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Dossou FC; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Takassi OE; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Djadou KE; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Atakouma YD; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo., Gbadoe AD; Département de Pédiatrie, CHU Sylvanus Olympio, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo.
Jazyk: francouzština
Zdroj: The Pan African medical journal [Pan Afr Med J] 2024 Apr 03; Vol. 47, pp. 162. Date of Electronic Publication: 2024 Apr 03 (Print Publication: 2024).
DOI: 10.11604/pamj.2024.47.162.33754
Abstrakt: Introduction: vaso-occlusive crisis (VOC) is the most common manifestation of sickle cell disease and the leading cause of hospitalization among affected children. The purpose of this study is to describe the clinical features of severe VOCs, to determine the etiologies of infectious syndromes that accompany them and to describe their management.
Methods: we conducted a descriptive cross-sectional study of 137 adult patients with sickle cell disease hospitalised for severe VOC in the Paediatric Department of the Sylvanus Olympio University Hospital from 1 st January 2009 to 31 st December 2011.
Results: the majority of patients (n=98; 71.5%) had homozygous sickle cell (SS), followed by double heterozygous SC disease (n=28; 20.5). The median of consultation time was 4.7 ± 4.4 days. Treatment before admission was based on antibiotics (28.5%). VOCs were mainly osteoarticular (70.8%). In 98.5% of cases, an associated bacterial infection was confirmed (48.9%) or suspected (49.6%). The main etiologies included acute chest syndrome (26.3%), acute osteomyelitis (10.9%), urinary tract infection (6.6%) and septicaemia (3.6%). One germ was isolated from 14.6% of patients: Escherichia coli (30%), followed by Klebsiella pneumoniae (25%), Staphylococcus aureus (15%), Salmonella typhi (10%), Streptococcus pneumoniae (5%), Streptococcus D (5%), Enterobacter (5%) and Acinetobacter (5%). Mortality rate was 2.2%. The average length of stay in hospital was 11.4 ± 8.8 days.
Conclusion: severe sickle cell-related vaso-occlusive crisis is mainly associated with bacterial infections in tropical environments. Appropriate and early antibiotic therapy is the essential therapeutic means to prevent or treat these patients.
Competing Interests: Les auteurs ne déclarent aucun conflit d´intérêts.
(Copyright: Koffi Mawuse Guedenon et al.)
Databáze: MEDLINE
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