Comparative Study on the Chemical Composition and Biological Activities of the Essential Oils of Lavandula angustifolia and Lavandula x intermedia Cultivated in Lebanon.

Autor: Massoud RI; Department of Chemistry, Faculty of Science, Beirut Arab University, P.O. Box 11-5020, Riad El Solh, Beirut 11072809, Lebanon., Bouaziz M; Laboratory of Electrochemistry and Environment, National School of Engineers of Sfax, University of Sfax, Sfax BP117 33038, Tunisia., Abdallah H; Department of Chemistry, Faculty of Sciences I, Lebanese University, Hadath Campus, Beirut 11-5020, Lebanon., Zeiz A; Department of Biological Sciences, Faculty of Science, Beirut Arab University, P.O. Box 11-5020, Beirut 11072809, Lebanon., Flamini G; Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, Pisa 56126, Italy., El-Dakdouki MH; Department of Chemistry, Faculty of Science, Beirut Arab University, P.O. Box 11-5020, Riad El Solh, Beirut 11072809, Lebanon.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2024 Jul 04; Vol. 9 (28), pp. 30244-30255. Date of Electronic Publication: 2024 Jul 04 (Print Publication: 2024).
DOI: 10.1021/acsomega.4c00313
Abstrakt: The phytochemical profile of essential oils is influenced by genetic and paragenetic factors. In this research, we studied the essential oils of Lavandula angustifolia and Lavandula x intermedia cultivated in Lebanon. The latter is a cross hybrid between Lavandula angustifolia and Lavandula latifolia and is also known as lavandin and Lavandula hybrida . Specifically, the chemical composition and biological activities (antibacterial, antioxidant, anticancer, and hemolytic) of the essential oils were assessed. GC-MS results showed marked differences in the chemical compositions of the oils. For example, linalool was more abundant in L. x intermedia (44.15%) than in L. angustifolia (32%), while an opposite trend was observed for the percentages of 1,8-cineole (8.6% in L. angustifolia and 4.0% in L. x intermedia ). FTIR analysis confirmed the richness of both oils in monoterpenes and sesquiterpenes. In terms of antioxidant activity, L. angustifolia essential oil demonstrated significantly better activity (IC 50 = 5.24 ± 1.20 mg/mL) compared to L. x intermedia oil in the DPPH radical scavenging assay. MTT cell viability assays revealed that L. angustifolia essential oil was a slightly more potent antiproliferative agent than L. x intermedia oil on human colorectal (HCT-116) and human breast (MCF-7) cancer cells. The antibacterial activity of the essential oils was tested against Staphylococcus aureus , Staphylococcus epidermidis , Enterococcus faecalis , Escherichia coli , and Serratia marcescens . Both oils showed good antibacterial activities with MIC values of 0.174 and 0.169 mg/mL for L. angustifolia and L. x intermedia oils, respectively. MBC determinations revealed that the antibacterial activity was bactericidal against all bacteria, except Staphylococcus aureus . Furthermore, both essential oils did not exhibit notable hemolytic activity on red blood cells. Overall, Lebanese L. angustifolia and L. x intermedia essential oils have promising industrial and medicinal values.
Competing Interests: The authors declare no competing financial interest.
(© 2024 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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