Spiroconjugated 1,2,3-triazolo[5,1- b ]1,3,4-thiadiazine stimulates functional activity of fibroblasts under skin injury regeneration.

Autor:	Petrova IM; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia., Chebanova SI; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia., Khatsko SL; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.; Federal State Budgetary Scientific Institution 'Ural Federal Agrarian Scientific Research Centre, Ural Branch of Russian Academy of Sciences', Yekaterinburg, 620142, Russia., Kalinina TA; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia., Zaitsev DV; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.; Ural State Mining University, Yekaterinburg, 620144, Russia., Glukhareva TV; Ural Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Jazyk:	angličtina
Zdroj:	Research in pharmaceutical sciences [Res Pharm Sci] 2024 Jul 01; Vol. 19 (3), pp. 267-275. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).
DOI:	10.4103/RPS.RPS_74_23
Abstrakt:	Background and Purpose: One of the most important mechanisms of tissue regeneration is the high functional activity of cells, including proliferation. Currently, there are practically no effective skin cell activators on the pharmaceutical market. The purpose of this work was to demonstrate the stimulating effect of spiroconjugated 1,2,3-triazolo[5,1- b ]1,3,4-thiadiazine (STT) on the functional activity of fibroblasts. Experimental Approach: STT containing ointment for dermal application was made. To assess in vivo effect of the STT a linear wound model in rats was tested. A combination of histological techniques and mechanical testing was employed to estimate the stimulating effect of STT on the functional activity of fibroblasts. Findings/results: The STT significantly increased the number of fibroblasts as well as the density and order of produced collagen fibers in the dermis during the wound healing process. As a result, a tissue was formed at the site of damage with the structure corresponding to normal skin. In addition, skin functions were restored, in particular mechanically. Conclusion and Implications: The results suggested the stimulating effect of the STT on fibroblast activity and demonstrated its potential for skin regeneration. Competing Interests: The authors declared no conflicts of interest in this study. (Copyright: © 2024 Research in Pharmaceutical Sciences.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu