Neuroprotective effects of Tradescantia spathacea tea bioactives in Parkinson's disease: In vivo proof-of-concept.

Autor:	Lopes LES; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., da Silva Barroso S; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Caldas JKM; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Vasconcelos PR; Embrapa Agroindústria Tropical, Rua Dra. Sara Mesquita, 2.270, Bairro Planalto do Pici, Fortaleza, CEP 60511-110, Ceará, Brazil., Canuto KM; Embrapa Agroindústria Tropical, Rua Dra. Sara Mesquita, 2.270, Bairro Planalto do Pici, Fortaleza, CEP 60511-110, Ceará, Brazil., Dariva C; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil.; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Santos KS; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Severino P; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil.; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Cardoso JC; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil.; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil., Souto EB; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal.; UCIBIO - Applied Molecular Biosciences Unit, MEDTECH, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal., Gomes MZ; Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil.; Research and Technology Institute (ITP), Av. Murilo Dantas, 300, Aracaju, CEP 49032-490, Sergipe, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of traditional and complementary medicine [J Tradit Complement Med] 2024 Jan 08; Vol. 14 (4), pp. 435-445. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2024).
DOI:	10.1016/j.jtcme.2024.01.003
Abstrakt:	Background and Aim: Tradescantia spathacea ( T. spathacea ) is a traditional medicinal plant from Central America and its tea, obtained by infusion, has been recognized as a functional food. The aim of this work was to investigate the effects of dry tea containing biocompounds from T. spathacea tea on motor and emotional behavior, as well as tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP) expression in 6-hydroxydopamine (6-OHDA)-lesioned rats. Experimental Procedure: Bioactives were identified by Ultra Performance Liquid Chromatography (UPLC) and an in vivo study in male Wistar rats was run as proof of concept of neuroprotective effects of DTTS. Results and Conclusion: We found 15 biocompounds that had not been previously reported in T. spathacea : the UPLC-QTOF-MS/MS allowed identification five phenolic acids, one coumarin, two flavonoids, one iridoid, one phenylpropanoid glycoside, and six fatty acid derivatives. The dry tea of T. spathacea (DTTS) presented significant antioxidant activity and high contents of phenolic compounds and flavonoids. Doses of 10, 30, and 100 mg/kg of DTTS were protective against dopaminergic neurodegeneration and exhibited modulatory action on the astrocyte-mediated neuroinflammatory response. Behavioral tests showed that 30 mg/kg of DTTS counteracted motor impairment, while 100 mg/kg produced an anxiolytic effect. The DTTS could be, therefore, a promising strategy for the management of Parkinson's disease. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.)
Databáze:	MEDLINE
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