Predictors of methotrexate adherence and patient's awareness of it in rheumatoid arthritis and its effect on quality of life.

Autor:	Mohamed M; Clinical Pharmacist at Medical Administration, Fayoum University, Egypt., El-Maboud A; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Cairo, Egypt., Salem HF; Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Cairo, Egypt., Salem MN; Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Cairo, Egypt., Elmaaty MA; Senior Clinical Pharmacist at the Children Cancer Hospital in Egypt, Beni-Suef University, Cairo, Egypt., Eissa N; Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates., Said ASA; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Cairo, Egypt.; Department of Clinical Pharmacy, College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates., Hussein RRS; Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of pharmaceutical policy and practice [J Pharm Policy Pract] 2024 Jul 18; Vol. 17 (1), pp. 2365933. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
DOI:	10.1080/20523211.2024.2365933
Abstrakt:	Introduction: Adherence studies among rheumatoid arthritis (RA) patients, in Egypt and throughout the Middle East region, are lacking. This study aimed to evaluate methotrexate (MTX) adherence in Rheumatoid arthritis (RA) patients and to identify specific non-adherence predictors. Methods: A cross-sectional observational study included 300 RA patients who were administered MTX for at least one year. The survey was completed through direct interviews. The demographic patient data were collected (age, education, sex, work status, disease duration, duration of MTX administration and current dose). Patients' adherence to MTX predictors for non-adherence, MTX side effects and functional disability were assessed in the study. Results: Majority of respondents showed good MTX adherence, and more than 50% of patient's experienced MTX side effects. A large percentage of participants showed low knowledge about MTX nature and side effects. Most participants reported no or some difficulty in quality of life-related activities and functional disability. Conclusion: MTX adherence and awareness were positively correlated to many variables, including, age, educational level and disease duration, which in turn has its positive impact on the patient's quality of life. Still, more research is needed to determine the impact of non-adherence on the patient's health outcomes. Competing Interests: No potential conflict of interest was reported by the author(s). (© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze:	MEDLINE
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