The cellular protrusions for inter-cellular material transfer: similarities between filopodia, cytonemes, tunneling nanotubes, viruses, and extracellular vesicles.

Autor:	Hu HT; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan., Nishimura T; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan., Kawana H; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan., Dante RAS; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan., D'Angelo G; Institut Curie, PSL Research University, Centre national de la recherche scientifique (CNRS), Paris, France., Suetsugu S; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan.; Data Science Center, Nara Institute of Science and Technology, Nara, Japan.; Center for Digital Green-innovation, Nara Institute of Science and Technology, Nara, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Jul 05; Vol. 12, pp. 1422227. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024).
DOI:	10.3389/fcell.2024.1422227
Abstrakt:	Extracellular vesicles (EVs) are crucial for transferring bioactive materials between cells and play vital roles in both health and diseases. Cellular protrusions, including filopodia and microvilli, are generated by the bending of the plasma membrane and are considered to be rigid structures facilitating various cellular functions, such as cell migration, adhesion, and environment sensing. Compelling evidence suggests that these protrusions are dynamic and flexible structures that can serve as sources of a new class of EVs, highlighting the unique role they play in intercellular material transfer. Cytonemes are specialized filopodia protrusions that make direct contact with neighboring cells, mediating the transfer of bioactive materials between cells through their tips. In some cases, these tips fuse with the plasma membrane of neighboring cells, creating tunneling nanotubes that directly connect the cytosols of the adjacent cells. Additionally, virus particles can be released from infected cells through small bud-like of plasma membrane protrusions. These different types of protrusions, which can transfer bioactive materials, share common protein components, including I-BAR domain-containing proteins, actin cytoskeleton, and their regulatory proteins. The dynamic and flexible nature of these protrusions highlights their importance in cellular communication and material transfer within the body, including development, cancer progression, and other diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Hu, Nishimura, Kawana, Dante, D’Angelo and Suetsugu.)
Databáze:	MEDLINE
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