The potential ameliorative role of Dimercaptosuccinic acid against the toxicity of Titanium Dioxide Nanoparticles on Caelatura nilotica clams.

Autor: Abdel-Azeem HH; Department of Zoology, Faculty of Sciences, Menoufia University, Shebeen El-Koom, Egypt., Mohamed AH; Department of Zoology, Faculty of Sciences, Menoufia University, Shebeen El-Koom, Egypt., Osman GY; Department of Zoology, Faculty of Sciences, Menoufia University, Shebeen El-Koom, Egypt., AbdElhafez AR; Department of Zoology, Faculty of Sciences, Menoufia University, Shebeen El-Koom, Egypt., Sheir SK; Department of Zoology, Faculty of Sciences, Menoufia University, Shebeen El-Koom, Egypt.
Jazyk: angličtina
Zdroj: Journal of experimental zoology. Part A, Ecological and integrative physiology [J Exp Zool A Ecol Integr Physiol] 2024 Nov; Vol. 341 (9), pp. 1053-1065. Date of Electronic Publication: 2024 Jul 21.
DOI: 10.1002/jez.2848
Abstrakt: The prevalent use of nanoparticles has adverse negative effects on biosystems. Subsequently, this study aimed to use Caelatura nilotica to assess the ecotoxicity of TiO 2 NPs and how Dimercaptosuccinic acid (DMSA) improves these effects. Two concentrations of TiO 2 NPs (25 and 150 µg/L) were used for 28 days. TiO 2 NPs bioaccumulation, gonadal weight, gonado-somatic index, and histopathological alterations of gonads were determined. The tissues' accumulation of TiO2 NPs was concentration-time-dependent: it was 78.5 ± 28.93 μg/g dry weight in the exposed clams to 150 µg/L TiO 2 NPs after 4 weeks of exposure. The gonadal weight and gonado-somatic index significantly decreased of the exposed group to 150 µg/L TiO 2 NPs over the experimental period that they ended with values (1.01 ± 0.57 gm, 19.15 ± 7.75%, respectively). There are some histological alterations in the gonads of C. nilotica such as necrosis, deteriorated connective tissue, increased fibrous tissue, a reduced presence of mature sperms and mature ova, and irregular shapes of testicular/ovarian follicles. When using Dimercaptosuccinic acid (DMSA), this led to a reduction in accumulation of TiO 2 NPs by the end of the experiment. So, C. nilotica is a promising model to reflect the adverse nano-toxics. DMSA emerges as a potentially valuable chelating agent that abolishes the negative effects of these nanoparticles.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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