Effects of early monocular enucleation on cortical spreading depression in well-nourished and malnourished adult rats.

Autor: Guedes RCA; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil., Monteiro JS; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil., de Biase S; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil., de Melo APR; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil., Borba JMC; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil., Diniz CWP; Lab of Neurodegeneration and Infection, ICB, HUJBB, Universidade Federal do Para, Belém, PA, 66075-110, Brazil., de Carvalho Noya AGAF; Center of Health Sciences, Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-630, Brazil., Prieto SCG; Center of Health Sciences, Nutrition department, Universidade Federal de Pernambuco, Recife, PE, 50670901, Brazil. sonicdc30@gmail.com.
Jazyk: angličtina
Zdroj: Experimental brain research [Exp Brain Res] 2024 Sep; Vol. 242 (9), pp. 2241-2247. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1007/s00221-024-06893-w
Abstrakt: Sensory development is a complex process that can influence physiological and pathological factors. In laterally-eyed mammals, monocular enucleation (ME) during development and the subsequent lack of external sensory stimuli can result in permanent morphological and physiological changes. Malnutrition, especially in early life, also can cause permanent morphofunctional changes due to inadequate nutrient intake in both hemispheres. This study investigated the effects of early (postnatal day 7) ME and malnutrition during the suckling period on cortical excitability in adulthood (110-140 days of life). For this, we compared the speed propagation of cortical spreading depression in the occipital and parietal cortex of malnourished and well-nourished adult rats, previously suckled small-sized litters with three pups (L3/dam) medium-sized litters with six pups (L6/dam), and large-sized litters with twelve pups (L12/dam). The CSD velocity was augmented by the ME in the contralateral side of the removed eye in the parietal and occipital cortex. These findings suggest that visual sensory input deprivation is associated with permanent functional changes in the visual pathways, which can alter cortical excitability and lead to modifications in CSD propagation.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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