GLYCOCINS: The sugar peppered antimicrobials.
Autor: | Ahlawat S; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India; Academy of Scientific and Innovation Research (AcSIR), Ghaziabad 201002, India., Shukla BN; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India., Singh V; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India., Sharma Y; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India., Choudhary P; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India. Electronic address: pravink315@gmail.com., Rao A; CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India; Academy of Scientific and Innovation Research (AcSIR), Ghaziabad 201002, India; Current address: Food Safety and Standards Authority of India (FSSAI), New Delhi 110002, India. Electronic address: raoalka@imtech.res.in. |
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Jazyk: | angličtina |
Zdroj: | Biotechnology advances [Biotechnol Adv] 2024 Oct; Vol. 75, pp. 108415. Date of Electronic Publication: 2024 Jul 19. |
DOI: | 10.1016/j.biotechadv.2024.108415 |
Abstrakt: | Glycosylated bacteriocins, known as glycocins, were first discovered in 2011. These bioactive peptides are produced by bacteria to gain survival advantages. They exhibit diverse types of glycans and demonstrate varied antimicrobial activity. Currently, there are 13 experimentally known glycocins, with over 250 identified in silico across different bacterial phyla. Notably, glycocins are recognized for their glycan-mediated antimicrobial activity, proving effective against drug-resistant and foodborne pathogens. Many glycocins contain rare S-linked glycans. Glycosyltransferases (GTs), responsible for transferring sugar to glycocins and involved in glycocin biosynthesis, often cluster together in the producer's genome. This clustering makes them valuable for custom glycoengineering with diverse substrate specificities. Heterologous expression of glycocins has paved the way for the establishment of microbial factories for glycopeptide and glycoconjugate production across various industries. In this review, we emphasize the primary roles of fully and partially characterized glycocins and their glycosylating enzymes. Additionally, we explore how specific glycan structures facilitate these functions in antibacterial activities. Furthermore, we discuss newer approaches and increasing efforts aimed at exploiting bacterial glycobiology for the development of food preservatives and as replacements or complements to traditional antibiotics, particularly in the face of antibiotic-resistant pathogenic bacteria. Competing Interests: Declaration of competing interest There are no conflicts to declare. (Copyright © 2024. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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