Plasma for prevention and treatment of glycocalyx degradation in trauma and sepsis.

Autor: Kravitz MS; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. mskravit@bidmc.harvard.edu., Kattouf N; Department of Emergency Medicine, Mount Sinai School of Medicine, New York, NY, USA., Stewart IJ; Department of Medicine, Uniformed Services University, Bethesda, MD, USA., Ginde AA; Department of Emergency Medicine, University of Colorado School of Medicines, Aurora, CO, USA., Schmidt EP; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Shapiro NI; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Critical care (London, England) [Crit Care] 2024 Jul 20; Vol. 28 (1), pp. 254. Date of Electronic Publication: 2024 Jul 20.
DOI: 10.1186/s13054-024-05026-7
Abstrakt: The endothelial glycocalyx, a gel-like layer that lines the luminal surface of blood vessels, is composed of proteoglycans, glycoproteins, and glycosaminoglycans. The endothelial glycocalyx plays an essential role in vascular homeostasis, and its degradation in trauma and sepsis can lead to microvascular dysfunction and organ injury. While there are no proven therapies for preventing or treating endothelial glycocalyx degradation, some initial literature suggests that plasma may have a therapeutic role in trauma and sepsis patients. Overall, the literature suggesting the use of plasma as a therapy for endothelial glycocalyx degradation is non-clinical basic science or exploratory. Plasma is an established therapy in the resuscitation of patients with hemorrhage for restoration of coagulation factors. However, plasma also contains other bioactive components, including sphingosine-1 phosphate, antithrombin, and adiponectin, which may protect and restore the endothelial glycocalyx, thereby helping to maintain or restore vascular homeostasis. This narrative review begins by describing the endothelial glycocalyx in health and disease: we discuss the overlapping disease mechanisms in trauma and sepsis that lead to its damage and introduce plasma transfusion as a potential therapy for prevention and treatment of endothelial glycocalyx degradation. Second, we review the literature on plasma as an exploratory therapy for endothelial glycocalyx degradation in trauma and sepsis. Third, we discuss the safety of plasma transfusion by reviewing the adverse events associated with plasma and other blood product transfusions, and we examine modern transfusion precautions that have enhanced the safety of plasma transfusion. We conclude that the literature proposes that plasma may have the potential to prevent and treat endothelial glycocalyx degradation in trauma and sepsis, indicating the need for further research.
(© 2024. The Author(s).)
Databáze: MEDLINE
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