Degradation of perineuronal nets in the medial prefrontal cortex promotes extinction and reduces reinstatement of methamphetamine-induced conditioned place preference in female mice.

Autor: Yao JY; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Zhao TS; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Guo ZR; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Li MQ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Lu XY; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Zou GJ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Chen ZR; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Liu Y; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Cui YH; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China., Li F; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China. Electronic address: fangli@csu.edu.cn., Li CQ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China. Electronic address: changqili@csu.edu.cn.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Aug 24; Vol. 472, pp. 115152. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1016/j.bbr.2024.115152
Abstrakt: The high rate of relapse to compulsive methamphetamine (MA)-taking and seeking behaviors after abstinence constitutes a major obstacle to the treatment of MA addiction. Perineuronal nets (PNNs), essential components of the extracellular matrix, play a critical role in synaptic function, learning, and memory. Abnormalities in PNNs have been closely linked to a series of neurological diseases, such as addiction. However, the exact role of PNNs in MA-induced related behaviors remains elusive. Here, we established a MA-induced conditioned place preference (CPP) paradigm in female mice and found that the number and average optical density of PNNs increased significantly in the medial prefrontal cortex (mPFC) of mice during the acquisition, extinction, and reinstatement stages of CPP. Notably, the removal of PNNs in the mPFC via chondroitinase ABC (ChABC) before extinction training not only facilitated the extinction of MA-induced CPP and attenuated the relapse of extinguished MA preference but also significantly reduced the activation of c-Fos in the mPFC. Similarly, the ablation of PNNs in the mPFC before reinstatement markedly lessened the reinstatement of MA-induced CPP, which was accompanied by the decreased expression of c-Fos in the mPFC. Collectively, our results provide more evidence for the implication of degradation of PNNs in facilitating extinction and preventing relapse of MA-induced CPP, which indicate that targeting PNNs may be an effective therapeutic option for MA-induced CPP memories.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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