Pathogenic role and diagnostic utility of interferon-α in histiocytic necrotizing lymphadenitis.

Autor: Kaneko S; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Shimbo A; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Irabu H; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Hatano M; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Takasawa K; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Kamiya T; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Akamine K; Department of Nephrology and Rheumatology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan., Tanaka T; Department of Pediatrics, Japanese Red Cross Otsu Hospital, Shiga, Japan., Minato T; Department of Pediatrics, Toyooka Hospital, Hyogo, Japan., Ono M; Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba, Japan., Yokoyama K; Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan., Arisaka A; Department of Pediatrics, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan., Yasumi T; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ueno K; Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan., Fujita S; Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan., Tanaka Y; Department of Pediatrics, Tsuchiura Kyodo General Hospital, Ibaraki, Japan., Hayashi D; Department of Pediatrics, Tsuchiura Kyodo General Hospital, Ibaraki, Japan., Nishikawa H; Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan., Fujita Y; Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan., Yuza Y; Department of Hematology/Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan., Mori M; Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Morio T; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Shimizu M; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: mshimizu.ped@tmd.ac.jp.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Sep; Vol. 266, pp. 110324. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1016/j.clim.2024.110324
Abstrakt: Purpose: Histiocytic necrotizing lymphadenitis (HNL) is an inflammatory disease of unknown etiology clinically characterized by painful lymphadenopathy. This study aimed to investigate the role of interferon (IFN)-α in the pathogenesis of HNL and the clinical significance of serum IFN-α levels for the diagnosis and monitoring of HNL disease activity.
Methods: This study enrolled 47 patients with HNL and 43 patients with other inflammatory diseases that require HNL differentiation including malignant lymphoma (ML), bacterial lymphadenitis, and Kawasaki disease. Expression of IFN-stimulated genes (ISGs) and MX1 in the lymph nodes was measured by real-time quantitative reverse transcription polymerase chain reaction and immunofluorescence staining, respectively. Enzyme-linked immunosorbent assay was used to quantify serum cytokine levels. The results were compared with the clinical features and disease course of HNL.
Results: Patients with HNL had a significantly elevated ISG expression in the lymph nodes compared with those with ML. MX1 and CD123, a specific marker of plasmacytoid dendritic cells (pDCs), were colocalized. In patients with HNL, serum IFN-α levels were significantly elevated and positively correlated with disease activity. The serum IFN-α level cutoff value for differentiating HNL from other diseases was 11.5 pg/mL.
Conclusion: IFN-α overproduction from pDCs may play a critical role in HNL pathogenesis. The serum IFN-α level may be a valuable biomarker for the diagnosis and monitoring of disease activity in patients with HNL.
Competing Interests: Declaration of competing interest All the authors declare that they have no relevant conflicts of interest.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: