Prevalence of anal high-risk human papillomavirus (HR-HPV) types in people living with HIV and a history of cancer.

Autor: Barquet-Muñoz SA; Dysplasia Department, Instituto Nacional de Cancerología, Mexico City, Mexico., López-Morales RA; Laboratory of Virus and Cancer, Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México & Instituto Nacional de Cancerología, Mexico City, Mexico., Stier EA; Department of Obstetrics and Gynecology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Mejorada-Pulido E; Dysplasia Department, Instituto Nacional de Cancerología, Mexico City, Mexico., Solís-Ramírez D; Dysplasia Department, Instituto Nacional de Cancerología, Mexico City, Mexico., Jay N; Anal Neoplasia Clinic, Research, and Education Center, University of California San Francisco, San Francisco, California, USA., Moctezuma P; Dysplasia Department, Instituto Nacional de Cancerología, Mexico City, Mexico., Morales-Aguirre M; Dysplasia Department, Instituto Nacional de Cancerología, Mexico City, Mexico., García-Carrancá A; Laboratory of Virus and Cancer, Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México & Instituto Nacional de Cancerología, Mexico City, Mexico., Méndez-Martínez R; Basic Research Unit, Virus, and Cancer Laboratory, Instituto Nacional de Cancerología, Mexico City, Mexico., Martin-Onraët A; Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City, Mexico., Pérez-Montiel D; Department of Surgical Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico., Mendoza-Palacios MJ; Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City, Mexico., Volkow P; Infectious Diseases Department, Instituto Nacional de Cancerología, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: HIV medicine [HIV Med] 2024 Oct; Vol. 25 (10), pp. 1145-1153. Date of Electronic Publication: 2024 Jun 20.
DOI: 10.1111/hiv.13684
Abstrakt: This study aimed to describe the prevalence of high-risk human papillomavirus (HR-HPV) types in the anal canal in a cohort of people living with HIV (PLWHIV) with a history of malignancy.
Setting: Referral tertiary care hospital for adult patients with cancer.
Methods: We reviewed data of patients from the AIDS Cancer Clinic on antiretroviral therapy in chronic control who were consecutively referred for high-resolution anoscopy (HRA), where they underwent anal evaluation, collection of specimens for anal cytology and anal human papillomavirus (HPV) followed by HRA with directed biopsy if needed.
Results: A total of 155 patients were included; 149 (96.1%) were men, all of them men who have sex with men (MSM); the median age was 39 (IQR 32-47) years; 105 (67.7%) with Kaposi sarcoma, 40 (25.8%) with non-Hodgkin lymphoma and 10 (6.4%) with other neoplasms; only 7 (4.5%) had active cancer. The prevalence of HR-HPV infection was 89% (n=138) (95% CI 83-93) with at least one HR-HPV infection, and 62% (96) had coinfection with at least two types; the median HR-HPV types of coinfection were 3 (IQR 2-4). The number of patients infected with HPV 16 was 64 (41.3%, 95% CI 33.8-49.3), HPV 18 was 74 (47.7%, 95% CI 39.9-55.7) and with both 35 (22.6%). Some 59 patients (38%) had high-grade squamous intraepithelial lesions (HSIL) and 49 (31.6%) had low-grade squamous intraepithelial lesions (LSIL). The prevalence of HR-HPV and HSIL among patients aged ≤35 and >35 years was the same.
Conclusions: In this cohort of PLWHIV with a history of malignancy we found a high prevalence of HR-HPV 16 and 18 and anal HSIL, even in persons aged ≤35 years. These data highlight the importance of anal cancer screening in PLWHIV and history of malignancy.
(© 2024 British HIV Association.)
Databáze: MEDLINE
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