Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

Autor:	Kloske CM; Alzheimer's Association, Chicago, Illinois, USA., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, Palo Alto, California, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA., Blue EE; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.; Institute for Public Health Genetics, University of Washington, Seattle, Washington, USA., Bowman GR; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Carrillo MC; Alzheimer's Association, Chicago, Illinois, USA., Chen X; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Chiba-Falek O; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA., Davis AA; Department of Neurology Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, Missouri, USA., Paolo GD; Denali Therapeutics Inc., San Francisco, California, USA., Garretti F; Ronald M. Loeb Center for Alzheimer's Disease, New York, New York, USA.; Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gate D; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Golden LR; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Heinecke JW; Department of Medicine, University of Washington, UV Medicine, Seattle, Washington, USA., Herz J; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Huang Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California, San Francisco, California, USA., Iadecola C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA., Johnson LA; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Kanekiyo T; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Karch CM; Department of Psychiatry, Washington University in St Louis, St. Louis, Missouri, USA., Khvorova A; RNA Therapeutic Institute, UMass Chan Medical School, Worcester, Massachusetts, USA., Koppes-den Hertog SJ; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Lamb BT; Stark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, Indiana, USA., Lawler PE; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.; The Tracy Family SILQ Center, Washington University School of Medicine, Indianapolis, Indiana, USA., Guen YL; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.; Institut du Cerveau-Paris Brain Institute-ICM, Paris, France., Litvinchuk A; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., Liu CC; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Mahinrad S; Alzheimer's Association, Chicago, Illinois, USA., Marcora E; Department of Genetics and Genomic Sciences, Nash Family Department of Neuroscience, Icahn Genomics Institute; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Michaelson DM; Sagol School of Neuroscience Tel Aviv University, Tel Aviv, Israel., Miller JJ; Departments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA., Morganti JM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.; Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA., Narayan PS; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, Center for Alzheimer's and Related Dementias (CARD), National Institutes of Health, Maryland, USA., Naslavsky MS; Human Genome and Stem-cell Research Center, Biosciences Institute, University of São Paulo, Rua do Matao, São Paulo, Brazil.; Hospital Israelita Albert Einstein, Avenida Albert Einstein, São Paulo, Brazil., Oosthoek M; Neurochemistry Laboratory, Department of Laboratory Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands., Ramachandran KV; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neuroscience, Columbia University Vagelos College of Physicians and Surgeons, New York, USA., Ramakrishnan A; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Raulin AC; Mayo Clinic Florida, Jacksonville, Florida, USA., Robert A; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Saleh RNM; Norwich Medical School, University of East Anglia, UK Clinical and Chemical Pathology, Norfolk, UK.; Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt., Sexton C; Alzheimer's Association, Chicago, Illinois, USA., Shah N; Lexeo Therapeutics, New York, New York, USA., Shue F; Mayo Clinic Florida, Jacksonville, Florida, USA., Sible IJ; University of Southern California, Los Angeles, California, USA., Soranno A; Washington University in Saint Louis, St. Louis, Missouri, USA, St. Louis, Missouri, USA., Strickland MR; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA., Tcw J; Department of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.; Bioinformatics Program, Faculty of Computing & Data Sciences, Boston University, Boston, Massachusetts, USA., Thierry M; Center for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA., Tsai LH; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Tuckey RA; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, Alabama, USA., Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA., van der Kant R; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, USA., Wang N; Mayo Clinic Rochester, Rochester, Minnesota, USA., Wellington CL; Djavad Mowafaghian Centre for Brain Health Department of Pathology and Laboratory Medicine International Collaboration on Repair Discoveries School of Biomedical Engineering University of British Columbia, Vancouver, Canada., Weninger SC; FBRI, Massachusetts, USA., Yassine HN; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Zhao N; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA., Bu G; Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong., Goate AM; Department of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Sep; Vol. 20 (9), pp. 6590-6605. Date of Electronic Publication: 2024 Jul 19.
DOI:	10.1002/alz.13877
Abstrakt:	Introduction: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research. Methods: In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function. Results: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field. Discussion: Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine. Highlights: APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE. (© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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