The impact of artificial liver support system on intestinal microbiota and serum bile acid profiles in patients with acute-on-chronic liver failure: a prospective cohort study.

Autor: Zeng Y; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China.; The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.17, Yongwai Zheng Street, Nanchang, 330000, China., Gan D; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China., Zhang K; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.17, Minde Road, Nanchang, 330000, China., Long T; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China., He Y; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China.; The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.128, Xiangshan North Road, Nanchang, 330000, China., Zhou R; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China.; The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.128, Xiangshan North Road, Nanchang, 330000, China., Liu S; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China.; The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.128, Xiangshan North Road, Nanchang, 330000, China., Xiong M; Infectious Diseases Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.167, Qingshan Lake Avenue, Nanchang, 330000, China. xml86005@163.com.; The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, NO.128, Xiangshan North Road, Nanchang, 330000, China. xml86005@163.com.
Jazyk: angličtina
Zdroj: Hepatology international [Hepatol Int] 2024 Oct; Vol. 18 (5), pp. 1540-1554. Date of Electronic Publication: 2024 Jul 20.
DOI: 10.1007/s12072-024-10712-3
Abstrakt: Background: Acute-on-chronic liver failure (ACLF) patients exhibit an imbalance in intestinal microbiota, and bile acids (BAs) can affect the composition of intestinal microbiota. Although Artificial liver support system (ALSS) is a treatment for ACLF, the impact of ALSS on intestinal microbiota and serum BA profiles of ACLF patients remains unclear.
Methods: A prospective study was conducted, which included 51 patients diagnosed with ACLF. These patients were stratified into two groups based on the utilization of an ALSS during their treatment period: a standard medical treatment group (SMT group), comprising 19 patients, and an ALSS combined with SMT group (ALSS group), comprising 32 patients. Blood and stool samples were collected from the patients on the day of admission and 14 days after treatment. Additionally, eight healthy controls were recruited, and their stool samples were also collected. The intestinal microbiota was sequenced using the 16S rRNA sequencing technique, while the serum BA profiles were determined using ultra-performance liquid chromatography/mass spectrometry.
Results: ACLF patients exhibited imbalances in intestinal microbiota and abnormalities in BA profiles. Compared to SMT alone, the combined ALSS and SMT was more effective in regulating intestinal microbiota imbalance and increasing the concentrations of ursodeoxycholic acid and glycoursodeoxycholic acid. Correlation analysis revealed a significant correlation between intestinal microbiota and Bas. Furthermore, the preliminary correlation heatmap indicated that the Faecalibaculum, Gemmiger, and taurochenodeoxycholic acid were associated with clinical improvement.
Conclusions: Our study identified the compositional characteristics of the intestinal microbiota and serum BA in ACLF patients, emphasizing the impact of ALSS on both intestinal microbiota and serum BA profiles.
(© 2024. Asian Pacific Association for the Study of the Liver.)
Databáze: MEDLINE
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