Histological evaluation of cardiac remodelling in equine athletes.

Autor: Nath LC; University of Adelaide, Adelaide, Australia. lauracnath@gmail.com., Saljic A; University of Copenhagen, Copenhagen, Denmark., Buhl R; University of Copenhagen, Copenhagen, Denmark., Elliott A; University of Adelaide, Adelaide, Australia., La Gerche A; St Vincents Institute Medical Research, Fitzroy, Australia., Ye C; University of Copenhagen, Copenhagen, Denmark., Schmidt Royal H; University of Copenhagen, Copenhagen, Denmark., Lundgren Virklund K; University of Copenhagen, Copenhagen, Denmark., Agbaedeng TA; University of Adelaide, Adelaide, Australia., Stent A; University of Melbourne, Parkville, Australia., Franklin S; University of Adelaide, Adelaide, Australia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 19; Vol. 14 (1), pp. 16709. Date of Electronic Publication: 2024 Jul 19.
DOI: 10.1038/s41598-024-67621-6
Abstrakt: Approximately 1-2 per 100,000 young athletes die from sudden cardiac death (SCD) and extreme exercise may be associated with myocardial scar and arrhythmias. Racehorses have a high prevalence of atrial fibrillation (AF) and SCD but the presence of myocardial scar and inflammation has not been evaluated. Cardiac tissues from the left (LAA) and right (RAA) atrial appendages, left ventricular anterior (LVAPM) and posterior (LVPPM) papillary muscles, and right side of the interventricular septum (IVS-R) were harvested from racehorses with sudden cardiac death (SCD, n = 16) or other fatal injuries (OFI, n = 17), constituting the athletic group (ATH, n = 33), and compared to sedentary horses (SED, n = 10). Horses in the ATH group had myocyte hypertrophy at all sites; increased fibrosis at all sites other than the LAA; increased fibroblast infiltration but a reduction in the overall extracellular matrix (ECM) volume in the RAA, LVAPM, and IVS-R compared to SED horses. In this horse model, athletic conditioning was associated with myocyte hypertrophy and a reduction in ECM. There was an excess of fibrocyte infiltration and focal fibrosis that was not present in non-athletic horses, raising the possibility of an exercise-induced pro-fibrotic substrate.
(© 2024. The Author(s).)
Databáze: MEDLINE
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