The timing of sleep spindles is modulated by the respiratory cycle in humans.

Autor: Ghibaudo V; Lyon Neuroscience Research Centre, INSERM U 1028/CNRS UMR5292, Bron, France., Juventin M; Lyon Neuroscience Research Centre, INSERM U 1028/CNRS UMR5292, Bron, France., Buonviso N; Lyon Neuroscience Research Centre, INSERM U 1028/CNRS UMR5292, Bron, France., Peter-Derex L; Lyon Neuroscience Research Centre, INSERM U 1028/CNRS UMR5292, Bron, France; Centre for Sleep Medicine and Respiratory Diseases, Hospices Civils de Lyon, Lyon 1 University, Lyon, France. Electronic address: Laure.peter-derex@chu-lyon.fr.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2024 Oct; Vol. 166, pp. 252-261. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.clinph.2024.06.014
Abstrakt: Objective: Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether sleep oscillations are also respiration-modulated in humans remains open. In this work, we investigated the influence of breathing on sleep spindles during non-rapid-eye-movement sleep in humans.
Methods: Full night polysomnography of twenty healthy participants were analysed. Spindles and slow waves were automatically detected during N2 and N3 stages. Spindle-related sigma power as well as spindle and slow wave events were analysed according to the respiratory phase.
Results: We found a significant coupling between both slow and fast spindles and the respiration cycle, with enhanced sigma activity and occurrence probability of spindles during the middle part of the expiration phase. A different coupling was observed for slow waves negative peaks which were rather distributed around the two respiration phase transitions.
Conclusion: Our findings suggest that breathing cycle influences the dynamics of brain activity during non-rapid-eye-movement sleep.
Significance: This coupling may enable sleep spindles to synchronize with other sleep oscillations and facilitate information transfer between distributed brain networks.
(Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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