A new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry for highly sensitive detection of trace exhaled ethylene.

Autor: Zhang B; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China., Hua L; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China., Fan Z; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China., Wen Y; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China., Zhang L; Affiliated Zhongshan Hospital of Dalian University, 6 Jiefang Road, Dalian, 116001, People's Republic of China., Xie Y; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China., Gao Y; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China., Jiang J; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China. Electronic address: jjc@dicp.ac.cn., Li H; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; Liaoning Key Laboratory for Mass Spectrometry Technology and Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China; Dalian Key Laboratory for Online Analytical Instrumentation, 457 Zhongshan Road, Dalian, 116023, People's Republic of China. Electronic address: hli@dicp.ac.cn.
Jazyk: angličtina
Zdroj: Analytica chimica acta [Anal Chim Acta] 2024 Aug 15; Vol. 1317, pp. 342910. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1016/j.aca.2024.342910
Abstrakt: Highly sensitive and rapid detection of ethylene, the smallest alkene of great significance in human physiological metabolism remains a great challenge. In this study, we developed a new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry (PSCI-TOFMS) for trace exhaled ethylene detection. An intriguing ionization phenomenon involving a substitution reaction between the CH 2 Br 2 + reactant ion and ethylene molecule was discovered and studied for the first time. The formation of readily identifiable [CH 2 Br·C 2 H 4 ] + product ion greatly enhanced the ionization efficiency of ethylene, which led to approximately 800-fold improvement of signal intensity over that in single photon ionization mode. The CH 2 Br 2 + reactant ion intensity and ion-molecule reaction time were optimized, and a Nafion tube was employed to eliminate the influence of humidity on the ionization of ethylene. Consequently, a limit of detection (LOD) as low as 0.1 ppbv for ethylene was attained within 30 s at 100 % relative humidity. The application of PSCI-TOFMS on the rapid detection of trace amounts of exhaled ethylene from healthy smoker and non-smoker volunteers demonstrated the satisfactory performance and potential of this system for trace ethylene measurement in clinical diagnosis, atmospheric measurement, and process monitoring.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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