Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer's disease.

Autor: Hari E; Graduate School of Health Sciences, Istanbul University, 34216 Istanbul, Turkey; Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: emrehr@hotmail.com., Ulasoglu-Yildiz C; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: cigdemulasoglu@gmail.com., Kurt E; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: elifkurt@istanbul.edu.tr., Bayram A; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: ali.bayram@istanbul.edu.tr., Gurvit H; Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey. Electronic address: gurvit@istanbul.edu.tr., Demiralp T; Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, 34093 Istanbul, Turkey. Electronic address: demiralp@istanbul.edu.tr.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2024 Sep; Vol. 165, pp. 127-137. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.clinph.2024.06.018
Abstrakt: Objective: Memory processes known to be impaired in Alzheimer's disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.
Methods: MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei.
Results: In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group.
Conclusions: Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD.
Significance: Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD.
(Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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