The oxidative stress-dependent pulmonary inflammation of inhalable multi-walled carbon nanotube-containing nano-concrete dust and its comparison with conventional concrete dust and DQ12.

Autor: Bae E; Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea., Kim S; Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea., Sung JH; Bio Division, Korea Conformity Laboratories, Incheon 21999, Republic of Korea., Kim JH; Construction Division, Korea Conformity Laboratories, Cheongju 28115, Republic of Korea., Jung SH; Construction Division, Korea Conformity Laboratories, Cheongju 28115, Republic of Korea., Song KS; Bio Division, Korea Conformity Laboratories, Incheon 21999, Republic of Korea., Cho WS; Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea. Electronic address: wcho@dau.ac.kr.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 Sep 05; Vol. 476, pp. 135214. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1016/j.jhazmat.2024.135214
Abstrakt: Nano-concrete, which is an admixture of nanomaterials in concrete recipes, has been investigated to overcome the limitations of existing concrete, such as its stability and strength. However, there is no information on the human health effects of broken-down dust released during the construction and demolition efforts. In this study, we prepared an inhalable fraction of multi-walled carbon nanotube-containing nano-concrete dust and performed comparative toxicity studies with conventional concrete dust and DQ12 using a rat intratracheal instillation model. Although the recipes for concrete and nano-concrete are entirely different, the pulverized dust samples showed similar physicochemical properties, such as 0.46-0.48 µm diameter and chemical composition. Both concrete and nano-concrete dust exhibited similar patterns and magnitudes, representing acute neutrophilic inflammation and chronic active inflammation with lymphocyte infiltration. The toxicity endpoints of the tested particles at both time points showed an excellent correlation with the reactive oxygen species levels released from the alveolar macrophages, highlighting that alveolar macrophages are the primary target cells and that the oxidative stress paradigm is the main toxicity mechanism of the tested particles. In addition, the toxicity potentials of both concrete and nano-concrete dust were more than 10 times lower than that of DQ12.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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