Chemotherapy effects on bone mineral density and microstructure in women with breast cancer.

Autor: Kuba S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-Machi, Nagasaki, 852-8501, Japan. skuba@nagasaki-u.ac.jp., Niimi R; Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Chiba K; Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Matsumoto M; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Hara Y; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Fukushima A; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Tanaka A; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Akashi M; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-Machi, Nagasaki, 852-8501, Japan., Morita M; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-Machi, Nagasaki, 852-8501, Japan., Inamasu E; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Otsubo R; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Kanetaka K; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-Machi, Nagasaki, 852-8501, Japan., Osaki M; Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Matsumoto K; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Eguchi S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-Machi, Nagasaki, 852-8501, Japan.
Jazyk: angličtina
Zdroj: Journal of bone and mineral metabolism [J Bone Miner Metab] 2024 Sep; Vol. 42 (5), pp. 591-599. Date of Electronic Publication: 2024 Jul 19.
DOI: 10.1007/s00774-024-01526-2
Abstrakt: Introduction: Chemotherapy involves the administration of steroids to prevent nausea and vomiting; however, its effect on bone microstructure remains unknown. This study aimed to evaluate the changes in bone mineral density (BMD) and bone microstructure associated with chemotherapy using high-resolution peripheral quantitative computed tomography (HR-pQCT) in women with early breast cancer.
Materials and Methods: This prospective single-arm observational study included non-osteoporotic, postmenopausal women with breast cancer. The patients underwent dual-energy X-ray absorptiometry (DXA), HR-pQCT, and tartrate-resistant acid phosphatase-5b (TRACP-5b) or procollagen type-I N-terminal propeptide (P1NP) measurements at baseline, end of chemotherapy, and 6 months after chemotherapy. The primary endpoint was the change in total volumetric BMD at the distal tibia and radius.
Results: Eighteen women were included in the study (median age: 57 years; range: 55-62 years). At 6 months after chemotherapy, HR-pQCT indicated a significant decrease in total volumetric BMD (median: distal tibia -4.5%, p < 0.01; distal radius -2.3%, p < 0.01), cortical volumetric BMD (-1.9%, p < 0.01;  -0.8%, p = 0.07, respectively), and trabecular volumetric BMD (-1.1%, p = 0.09;  -3.0%, p < 0.01, respectively). The DXA BMD also showed a significant decrease in the lumbar spine (median: -4.5%, p < 0.01), total hip (-5.5%, p < 0.01), and femoral neck (-4.2%, p < 0.01). TRACP-5b and P1NP levels were significantly increased at the end of chemotherapy compared to baseline.
Conclusion: Postmenopausal women undergoing chemotherapy for early breast cancer experienced significant BMD deterioration in weight-bearing bone, which was further reduced 6 months after chemotherapy.
(© 2024. The Japanese Society Bone and Mineral Research.)
Databáze: MEDLINE
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