The effect of heart rate variability on the choroidal vascularity of the optical coherence tomography and angiography in central serous chorioretinopathy.

Autor: Hwang BE; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea., Kim JY; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea., Park YH; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. parkyh@catholic.ac.kr.; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea. parkyh@catholic.ac.kr.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Dec; Vol. 262 (12), pp. 3825-3835. Date of Electronic Publication: 2024 Jul 19.
DOI: 10.1007/s00417-024-06575-x
Abstrakt: Purpose: To investigate the correlation between the autonomic nervous system and choroidal vascularity in patients with central serous chorioretinopathy (CSC), using heart rate variability (HRV) analysis, optical coherence tomography (OCT) and OCT angiography (OCTA).
Methods: We retrospectively analyzed data of 25 patients with unilateral CSC (50 eyes, including the unaffected fellow eyes) and 25 healthy controls. The assessment involved a 5-minute HRV analysis encompassing both frequency and time domains, especially low frequency (LF), high frequency (HF), and LF/HF ratio. In OCT (12 × 9 mm) and en-face OCTA (3 × 3 mm) scans, we measured parameters including choroidal vascularity index (CVI), choroidal vessel density in the middle and deep layers, and choriocapillaris flow void. Regression analysis was conducted to elucidate the associations between HRV parameters and OCT/OCTA measurements.
Results: Normalized LF(LFnorm) and LF/HF ratios were higher in patients with CSC than in healthy controls. LFnorm and the log-transformed ratio of LF to HF [log(LF/HF)] demonstrated a significant and borderline correlation with CVI in the linear regression analysis (P = 0.040, R 2  = 0.171, and P = 0.059, R 2  = 0.147, respectively). Both CVI and deep choroid vessel density showed a more significant association with LFnorm and log (LF/HF) in the non-linear quadratic regression analysis than in the linear analysis (all, P < 0.04, R 2  > 0.25).
Conclusion: The frequency-domain parameters of HRV, including LFnorm and log (LF/HF), demonstrated a significant association with indicators reflective of large choroidal vessel luminal area on macular OCT/OCTA scans. This observation implies complicated modulation of choroidal blood flow by the autonomic nervous system in CSC.
Competing Interests: Declarations. Compliance with ethical standards: Owing to the retrospective nature of image analysis and anonymized data of this study, the need of informed consent procedures was waived by the Institutional Review Board (IRB) of Seoul St. Mary’s Hospital. Waiver of informed consent was granted by the IRB in accordance with the provisions of the IRB. All protocols were also approved by the IRB of Seoul St. Mary’s Hospital, The Catholic University of Korea (KC23RISI0791). < The provisions of IRB > The study corresponds to [waiver of informed consent process] for the following reasons in accordance with relevant domestic and international regulations. 1 > Retrospective study of medical record 2 > It is practically impossible to obtain consent from the study subject in the course of the study or has a serious impact on the validity of the study 3 > There is no reason to estimate the subject’s refusal to consent, and even if consent is exempted, the risk to the subject is extremely low. Competing interests: None of the authors have any conflicting interests to disclose.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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