Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis.
| Autor: | Wasserman S; Institute for Infection and Immunity, St. George's, University of London, London, United Kingdom.; Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Antilus-Sainte R; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Abdelgawad N; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Odjourian NM; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Cristaldo M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Dougher M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Kaya F; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Zimmerman M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA., Denti P; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Gengenbacher M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.; Hackensack Meridian School of Medicine, Nutley, New Jersey, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Aug 07; Vol. 68 (8), pp. e0078324. Date of Electronic Publication: 2024 Jul 19. |
| DOI: | 10.1128/aac.00783-24 |
| Abstrakt: | Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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