| Autor: |
Duan R; Department of Biostatistics, Harvard T.H. Chan School of Public Health., Tong J; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania., Lin L; Department of Epidemiology and Biostatistics, University of Arizona., Levine L; Department of Obstetrics and Gynecology, University of Pennsylvania., Sammel M; University of Colorado Denver., Stoddard J; University of Colorado Denver., Li T; University of Colorado Denver., Schmid CH; Department of Biostatistics, Brown University., Chu H; Statistical Research and Data Science Center, Pfizer Inc., Chen Y; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania. |
| Jazyk: |
angličtina |
| Zdroj: |
The annals of applied statistics [Ann Appl Stat] 2023 Mar; Vol. 17 (1), pp. 815-837. Date of Electronic Publication: 2023 Jan 24. |
| DOI: |
10.1214/22-aoas1652 |
| Abstrakt: |
The growing number of available treatment options has led to urgent needs for reliable answers when choosing the best course of treatment for a patient. As it is often infeasible to compare a large number of treatments in a single randomized controlled trial, multivariate network meta-analyses (NMAs) are used to synthesize evidence from trials of a subset of the treatments, where both efficacy and safety related outcomes are considered simultaneously. However, these large-scale multiple-outcome NMAs have created challenges to existing methods due to the increasing complexity of the unknown correlations between outcomes and treatment comparisons. In this paper, we proposed a new framework for PAtient-centered treatment ranking via Large-scale Multivariate network meta-analysis, termed as PALM, which includes a parsimonious modeling approach, a fast algorithm for parameter estimation and inference, a novel visualization tool for presenting multivariate outcomes, termed as the origami plot, as well as personalized treatment ranking procedures taking into account the individual's considerations on multiple outcomes. In application to an NMA that compares 14 treatment options for labor induction, we provided a comprehensive illustration of the proposed framework and demonstrated its computational efficiency and practicality, and we obtained new insights and evidence to support patient-centered clinical decision making. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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