Seroepidemiology of hepatitis B virus (HBV) and relationship to serum transaminase levels in Indian population.

Autor: Kumar M; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Seema K; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Kumar D; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Kumar A; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Sharma AK; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Boipai M; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India., Rani A; Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Jazyk: angličtina
Zdroj: Journal of family medicine and primary care [J Family Med Prim Care] 2024 Jun; Vol. 13 (6), pp. 2410-2415. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.4103/jfmpc.jfmpc_1746_23
Abstrakt: Background: Hepatitis B virus (HBV) infection is a serious public health issue that must be addressed.
Aim: The goal of this study was to investigate the correlation between serological status for hepatitis Be antigen (HBeAg)/anti-HBe, serum transaminase levels, and serum HBV-DNA in patients with chronic HBV infection.
Methods: A retrospective observational study with 620 patients with persistent HBV infection (mean age, 36.35 years; 506 men) was conducted. All patients tested positive for hepatitis B surface antigen (HBsAg). Liver profile, HBeAg, and anti-HBe antibody tests were conducted for all patients. Additionally, serum HBV DNA was examined using a DNA assay in these individuals.
Results: Of 620 patients, 114 (18.39%) were HBeAg-positive and 506 (81.61%) HBeAg-negative. A detectable level of HBV DNA was found in 89.79% of HBeAg-positive/anti-HBe negative patients compared to HBeAg-negative/anti-HBe positive carriers 33.69% ( P value <0.0001). The median viral load was significantly higher in HBeAg-positive cases (4.72 log10 copies/mL) than in HBeAg-negative individuals (4.23 log10 copies/mL; P = 0.997). Additionally, a higher proportion of HBeAg-positive samples ( P = 0.0001) had HBV-DNA levels above 10,000 copies/mL.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 Journal of Family Medicine and Primary Care.)
Databáze: MEDLINE
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