Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients.

Autor:	Elgenidy A; Faculty of Medicine, Cairo University, Cairo, Egypt.; These authors contributed equally to this article., Al-Kurdi MA; Faculty of Medicine, University of Aleppo, Aleppo, Syrian Arab Republic.; These authors contributed equally to this article., Ibrahim HAA; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt., Gad EF; Department of Pediatrics, Assiut University, Assiut 71516, Egypt., Awad AK; Faculty of Medicine Ain-Shams University, Cairo, Egypt., Caruana R; Mater dei Hospital, Msida, Malta., Diacono S; Mater dei Hospital, Msida, Malta., Sherif A; Faculty of Medicine, Beni Suef University, Beni Suef, Egypt., Elattar T; Faculty of Clinical Pharmacy, Al Azhar University, Cairo, Egypt., Al-Ghanam IE; Faculty of Medicine Ain-Shams University, Cairo, Egypt., Eldmaty AM; Faculty of Medicine, Cairo University, Cairo, Egypt., Abubasheer TM; Faculty of Medicine, Al-Quds University, Palestine., Afifi AM; Department of Surgery, University of Toledo Medical Center, Toledo, OH, USA., Elhoufey A; Department of Community Health Nursing, Alddrab University College, Jazan University, Jazan 45142, Saudi Arabia.; Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt., Dailah HG; Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia., Osman AM; Department of Pediatric Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt., Ezzat M; Department of Pediatrics, Faculty of Medicine, Al Azhar University, Cairo, Egypt., Gamal DA; Department of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, Egypt., Elmonier R; Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt., Hammour AE; Department of Pediatrics, Faculty of Medicine, Al Azhar University, Cairo, Egypt., Abougabal MT; Department of Pediatrics, Zagazig University, Zagazig, Egypt., Saad K; Department of Pediatrics, Assiut University, Assiut 71516, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of clinical medicine research [J Clin Med Res] 2024 Jun; Vol. 16 (6), pp. 310-318. Date of Electronic Publication: 2024 Jun 30.
DOI:	10.14740/jocmr5205
Abstrakt:	Background: Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes. Methods: We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death. Results: Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%). Conclusions: Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females. Competing Interests: All authors do not have a potential conflict of interest. (Copyright 2024, Elgenidy et al.)
Databáze:	MEDLINE
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