Fluoroestradiol PET-MRI imaging for detection of endometriosis lesions and symptom correlation.

Autor:	Oldan JD; Department of Radiology, University of North Carolina School of Medicine 2000 Old Clinic, Campus Box 7510, Chapel Hill, NC 27599-7510, United States of America., Lee YZ; Department of Radiology, University of North Carolina School of Medicine 2000 Old Clinic, Campus Box 7510, Chapel Hill, NC 27599-7510, United States of America., OIinger K; Department of Radiology, University of North Carolina School of Medicine 2000 Old Clinic, Campus Box 7510, Chapel Hill, NC 27599-7510, United States of America., Benefield TS; Department of Radiology, University of North Carolina School of Medicine 2000 Old Clinic, Campus Box 7510, Chapel Hill, NC 27599-7510, United States of America., Carey ET; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine 4010 Old Clinic Building, Campus Box 7570, United States of America., Abu-Alnadi ND; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine 4010 Old Clinic Building, Campus Box 7570, United States of America., Young SL; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine 4010 Old Clinic Building, Campus Box 7570, United States of America.
Jazyk:	angličtina
Zdroj:	American journal of nuclear medicine and molecular imaging [Am J Nucl Med Mol Imaging] 2024 Jun 15; Vol. 14 (3), pp. 182-188. Date of Electronic Publication: 2024 Jun 15 (Print Publication: 2024).
DOI:	10.62347/JOQM7920
Abstrakt:	Endometriosis is a common cause of infertility, pelvic pain, and dysmenorrhea and there are prior case reports of lesion detection using an 18F-fluoroestradiol (FES) tracer with positron emission tomography (PET). We aimed to further investigate the use of the FES tracer in the context of PET-magnetic resonance (PET-MR) imaging. We administered FES to 6 patients and then imaged them using a Siemens mMR PET-MR scanner. Each patient was taken to surgery within 30 days after imaging, and surgical visualization served as the gold-standard for diagnosis. PET did not prove to be as sensitive as MR (50% per-patient sensitivity versus 67% per-patient and 35% versus 48% per-lesion), and did not show any additional sites over and above MR. When MR was used to localize lesions on PET after imaging, there was insufficient evidence of an association between total tracer uptake and reported pain intensity (P=0.25). FES PET-MR offers no additional value to MR for endometriosis. Competing Interests: None. (AJNMMI Copyright © 2024.)
Databáze:	MEDLINE
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