Nanohole array integrated metal insulator metal (MIM) based structure employing dual mode SPR sensor for detection of Hemoglobin (Hb) in blood.

Autor:	Tasnim N; Optics and Photonics Research Group, Department of Electrical and Electronic Engineering, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka 1212, Bangladesh., Mohsin ASM; Optics and Photonics Research Group, Department of Electrical and Electronic Engineering, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka 1212, Bangladesh.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Jun 22; Vol. 10 (12), pp. e33445. Date of Electronic Publication: 2024 Jun 22 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e33445
Abstrakt:	Surface Plasmon Resonance (SPR) based optical biosensors are recently the most attractive sensing devices that can detect minor changes in refractive index. Multiple methods have been developed to design SPR based biosensors with high-performance and ease of fabrication. This research is about a grating based biosensor that utilizes Silver (Ag) and Titanium (Ti) to produce the SP resonance state. The structure has a resonance wavelength, which displays sensitivity to changes in the surrounding medium of the refractive index. The study has been conducted using numerical simulations, utilizing the finite-difference-time-domain (FDTD) method.The simulation results shows a sharp resonance peaks in the wavelength range of 450-700 nm with a remarkable sensitivity of 172 nm/RIU (for mode 1 at SPR peak 465 nm) and 515 nm/RIU (for mode 2 at SPR peak 585 nm), which is superior to other on-chip device. The investigation involves a comparative analysis of sensing performance, focusing on parameters like transmission, reflection, FWHM and Quality factor to measure the detection accuracy of the proposed material combination. Later, we employed this miniature biosensor device to detect hemoglobin concentrations in the blood. Our findings indicate that this developed structure has great potential for detecting any biomolecule, such as proteins, glucose, fructose, nucleic acids, and cells. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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