Comparison of salivary beta-defensin-1 levels in patients with periodontitis before and after phase I periodontal therapy.

Autor:	Ansari Moghadam S; Department of Periodontology, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Pishadast S; Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Gholami L; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada., Alijani E; Department of Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Ansari Moghadam A; Department of Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran., Hadilou M; Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Jazyk:	angličtina
Zdroj:	Journal of advanced periodontology & implant dentistry [J Adv Periodontol Implant Dent] 2024 Jan 29; Vol. 16 (1), pp. 30-35. Date of Electronic Publication: 2024 Jan 29 (Print Publication: 2024).
DOI:	10.34172/japid.2024.002
Abstrakt:	Background: This study compared human β-defensin 1 ( hBD-1 ) salivary levels in patients with periodontitis before and after phase I periodontal therapy. Methods: This controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in the intervention group had stage 3 grade B periodontitis with no systemic diseases and had not taken any medications in the last six months. The control group included participants with healthy periodontium. Before and after phase I periodontal therapy, salivary samples were collected from the intervention group. ELISA was used to measure hBD-1 levels. Results: Salivary levels of hBD-1 decreased after phase I periodontal treatment in periodontitis patients, approaching those in healthy individuals. However, this reduction was not statistically significant ( P =0.389). In patients with a probing depth (PD) of at least 3 mm, salivary levels of hBD-1 decreased significantly ( P =0.019) following the intervention. There was no significant correlation between changes in hBD-1 levels and clinical indices, such as clinical attachment loss (CAL), probing depth, or bleeding index (BI) ( P ˃0.05). Conclusion: The current study demonstrated promising results concerning a probable link between hBD-1 and periodontitis. However, more research with sufficiently large sample sizes and more robust study designs is necessary. Competing Interests: The authors declare that they have no competing interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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