Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT.

Autor:	Kusk MW; Radiography & Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.; Department of Radiology & Nuclear Medicine, University Hospital of Southern Denmark, Esbjerg 6700, Denmark.; Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense M 5230, Denmark., Hess S; Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense M 5230, Denmark.; Department of Nuclear Medicine, Odense University Hospital, Odense 5000, Denmark., Gerke O; Department of Nuclear Medicine, Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense 5000, Denmark., Kristensen LD; Department of Cardiology, University Hospital of Southern Denmark, Esbjerg 6700, Denmark., Oxlund CS; Department of Cardiology, University Hospital of Southern Denmark, Esbjerg 6700, Denmark., Ormstrup TE; Department of Radiology & Nuclear Medicine, University Hospital of Southern Denmark, Esbjerg 6700, Denmark., Christiansen JM; Department of Radiology & Nuclear Medicine, University Hospital of Southern Denmark, Esbjerg 6700, Denmark., Foley SJ; Radiography & Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Jazyk:	angličtina
Zdroj:	European journal of radiology open [Eur J Radiol Open] 2024 Jun 25; Vol. 13, pp. 100583. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).
DOI:	10.1016/j.ejro.2024.100583
Abstrakt:	Objectives: This prospective study tested the diagnostic accuracy, and absolute agreement with MRI of a low-dose CT protocol for left ventricular ejection fraction (LVEF) measurement. Furthermore we assessed its potential for combining it with Chest-Abdomen-Pelvis CT (CAP-CT) for a one-stop examination. Materials & Methods: Eighty-two patients underwent helical low-dose CT. Cardiac magnetic resonance imaging (MRI) was the reference standard. In fifty patients, CAP-CT was performed concurrently, using a modified injection protocol. In these, LVEF was measured with radioisotope cardiography (MUGA). Patients >18 years, without contrast media or MRI contraindications, were included. Bias was measured with Bland-Altman analysis, classification accuracy with Receiver Operating Characteristics, and inter-reader agreement with Intra-Class Correlation Coefficient (ICC). Correlation was examined using Pearson's correlation coefficients. CAP image quality was compared to previous scans with visual grading characteristics. Results: The mean CT dose-length-product (DLP) was 51.8 mGycm, for an estimated effective dose of 1.4 mSv, compared to 5.7 mSv for MUGA. CT LVEF bias was between 2 % and 10 %, overestimating end-diastolic volume. When corrected for bias, sensitivity and specificity of 100 and 98.5 % for classifying reduced LVEF (50 % MRI value) was achieved. ICC for MUGA was significantly lower than MRI and CT. Distinction of renal medulla and cortex was reduced in the CAP scan, but proportion of diagnostic scans was not significantly different from standard protocol. Conclusion: When corrected for inter-modality bias, CT classifies patients with reduced LVEF with high accuracy at a quarter of MUGA dose and can be combined with CAP-CT without loss of diagnostic quality. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Martin Weber Kusk reports financial support was provided by Radiograf Rådets Forskningsfond. Martin Weber Kusk reports financial support was provided by Esbjerg Fonden (I.C. Møllers Fond). Martin Weber Kusk reports financial support was provided by Karola Jørgensens Fond. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper (© 2024 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu