Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections in vitro and in vivo .

Autor: Wang Y; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.; University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn., Wu F; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.; University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn., Li Y; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn., Wang S; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.; University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn., Ren Y; University of Groningen and University Medical Center Groningen, Department of Orthodontics, Groningen, The Netherlands., Shi L; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn., van der Mei HC; University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl., Liu Y; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn.
Jazyk: angličtina
Zdroj: Materials horizons [Mater Horiz] 2024 Sep 30; Vol. 11 (19), pp. 4781-4790. Date of Electronic Publication: 2024 Sep 30.
DOI: 10.1039/d4mh00642a
Abstrakt: The overuse of antibiotics has led to the rapid development of multi-drug resistant bacteria, making antibiotics increasingly ineffective against bacterial infections. Consequently, there is an urgent need to develop alternative strategies to combat multi-drug-resistant bacterial infections. In this study, gold nanoparticles modified with ellagic acid (EA-AuNPs) were prepared using a simple and mild one-pot hydrothermal process. EA-AuNPs demonstrated high bactericidal efficacy and broad-spectrum antimicrobial activities against clinical isolates of the antibiotic-resistant ESKAPE pathogens. Furthermore, EA-AuNPs effectively disperse biofilms of multi-drug-resistant bacteria. Additionally, EA-AuNPs mitigated inflammatory responses at the bacterial infection sites. The combined bactericidal and anti-inflammatory treatment with EA-AuNPs resulted in faster curing of peritonitis caused by Staphylococcus aureus in mice compared to treatment with free EA or gentamicin. Moreover, transcriptome analysis revealed that EA-AuNPs exhibited a multi-targeting mechanism, making resistance development in pathogens more challenging than traditional antibiotics that recognize specific cellular targets. Overall, EA-AuNPs emerged as a promising antimicrobial agent against multi-drug-resistant bacterial infections.
Databáze: MEDLINE