Sorbate metal complexes as newer antibacterial, antibiofilm, and anticancer compounds.

Autor: Abousaty AI; Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Reda FM; Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Hassanin WA; Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Felifel WM; Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., El-Shwiniy WH; Department of Chemistry, College of Science, University of Bisha, 61922, Bisha, Saudi Arabia.; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Selim HMRM; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, P.O. Box 71666, Riyadh, 11597, Saudi Arabia.; Microbiology and Immunology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 35527, Egypt., Bendary MM; Department of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said, 42526, Egypt. micro_bendary@yahoo.com.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2024 Jul 18; Vol. 24 (1), pp. 262. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1186/s12866-024-03370-w
Abstrakt: Background: The ineffectiveness of treatments for infections caused by biofilm-producing pathogens and human carcinoma presents considerable challenges for global public health organizations. To tackle this issue, our study focused on exploring the potential of synthesizing new complexes of Co(II), Cu(II), Ni(II), and Zn(II) with sorbic acid to enhance its antibacterial, antibiofilm, and anticancer properties.
Methods: Four novel complexes were synthesized as solid phases by reacting sorbic acid with Co(II), Cu(II), Ni(II), and Zn(II). These complexes were characterized by various technique, including infrared spectra, UV-Visible spectroscopy, proton nuclear magnetic resonance (1H NMR), and thermal analysis techniques, including thermogravimetry (TG).
Results: The data acquired from all investigated chemical characterization methods confirmed the chemical structure of the sorbate metal complexes. These complexes exhibited antibacterial and antibiofilm properties against both Gram-positive and Gram-negative bacteria. Furthermore, these complexes enhanced the antibacterial effects of commonly used antibiotics, such as gentamicin and imipenem, with fractional inhibitory concentration (FIC) indices ≤ 0.5. Notably, the Cu(II) complex displayed the most potent antibacterial and antibiofilm activities, with minimum inhibitory concentration (MIC) values of 312.5 µg/mL and 625.0 µg/mL for Bacillus cereus and Escherichia coli, respectively. Additionally, in vitro assays using the methyl thiazolyl tetrazolium (MTT) method showed inhibitory effects on the growth of the human colon carcinoma cell line (HCT-116 cells) following treatment with the investigated metal complexes. The IC50 values for Co(II), Cu(II), Zn(II), and Ni(II) were 3230 µg/mL, 2110 µg/mL, 3730 µg/mL, and 2240 µg/mL, respectively.
Conclusion: Our findings offer potential for pharmaceutical companies to explore the development of novel combinations involving traditional antibiotics or anticancer drugs with sorbate copper complex.
(© 2024. The Author(s).)
Databáze: MEDLINE
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