The effect of human albumin administration on postoperative renal function following major surgery: a systematic review and meta-analysis.

Autor: Lee KS; Department of Anesthesiology and Pain Medicine, Eulji University Uijeongbu Eulji Medical Center, Eulji Uni-Versity School of Medicine, Uijeongbu, 11759, Republic of Korea., Kim JE; Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, 164, World Cup-Ro, Yeongtong-Gu, Suwon, 16499, Republic of Korea., Kang G; Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea., Won YJ; Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea., Choi YJ; Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea. yoonji07@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 18; Vol. 14 (1), pp. 16599. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1038/s41598-024-62495-0
Abstrakt: Optimal fluid management during major surgery is of considerable concern to anesthesiologists. Although crystalloids are the first choice for fluid management, the administration of large volumes of crystalloids is associated with poor postoperative outcomes. Albumin can be used for fluid management and may protect renal function. However, data regarding the effects of albumin administration on kidney function are conflicting. As such, the present study aimed to investigate the effect of albumin administration on renal function in patients undergoing major surgery and compare its effects with those of crystalloid fluid. The Embase, Medline, Web of Science, Cochrane Library, and KoreaMed databases were searched for relevant studies. The primary endpoint of the meta-analysis was the incidence of postoperative kidney injury, including acute kidney injury and renal replacement therapy. Twelve studies comprising 2311 patients were included; the primary endpoint was analyzed in four studies comprising 1749 patients. Perioperative albumin levels in patients undergoing major surgery did not significantly influence kidney dysfunction (p = 0.98). Postoperative fluid balance was less positive in patients who underwent major surgery and received albumin than in those who received crystalloids. Owing to the limitations of this meta-analysis, it remains unclear whether albumin administration during major surgery is better than crystalloid fluid for improving postoperative renal function.
(© 2024. The Author(s).)
Databáze: MEDLINE
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