Maternal inheritance of functional centrioles in two parthenogenetic nematodes.

Autor: Perrier A; Université Paris Cité, CNRS, Institut Jacques Monod, F-75013, Paris, France., Guiglielmoni N; Worm∼lab, Institute for Zoology, University of Cologne, Cologne, NRW, Germany., Naquin D; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Gorrichon K; Centre de Référence, d'Innovation, d'eXpertise et de transfert (CRefIX), US 039 CEA/INRIA/INSERM, Evry, France.; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, Direction de la Recherche Fondamentale, CEA, Evry, France., Thermes C; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Lameiras S; Institut Curie, PSL University, ICGex Next-Generation Sequencing Platform, 75005, Paris, France., Dammermann A; Max Perutz Labs, Vienna Biocenter Campus (VBC), 1030, Vienna, Austria.; University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, 1030, Vienna, Austria., Schiffer PH; Worm∼lab, Institute for Zoology, University of Cologne, Cologne, NRW, Germany., Brunstein M; Institut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, F-75012, Paris, France., Canman JC; Columbia University Irving Medical Center; Department of Pathology and Cell Biology, New York, NY, 10032, USA., Dumont J; Université Paris Cité, CNRS, Institut Jacques Monod, F-75013, Paris, France. Julien.dumont@ijm.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 18; Vol. 15 (1), pp. 6042. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1038/s41467-024-50427-5
Abstrakt: Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal. Centrioles are retained during male meiosis and, in most species, are reintroduced with the sperm during fertilization, restoring centriole numbers in embryos. In contrast, the presence, origin, and function of centrioles in parthenogenetic species is unknown. We found that centrioles are maternally inherited in two species of asexual parthenogenetic nematodes and identified two different strategies for maternal inheritance evolved in the two species. In Rhabditophanes diutinus, centrioles organize the poles of the meiotic spindle and are inherited by both the polar body and embryo. In Disploscapter pachys, the two pairs of centrioles remain close together and are inherited by the embryo only. Our results suggest that maternally-inherited centrioles organize the embryonic spindle poles and act as a symmetry-breaking cue to induce embryo polarization. Thus, in these parthenogenetic nematodes, centrioles are maternally-inherited and functionally replace their sperm-inherited counterparts in sexually reproducing species.
(© 2024. The Author(s).)
Databáze: MEDLINE
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