Prediction of adverse drug reactions in geriatric patients admitted to intensive care units.

Autor:	Marques Carizio FA; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., do Vale de Souza I; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil. Electronic address: isabellavale92@gmail.com., Zago Oliveira T; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., Sueli Silva L; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., Chaguri Alves Rodrigues N; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., Barbosa Zanetti MO; Departamento de Enfermería Psiquiátrica y Ciencias Humanas, Facultad de Enfermería de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., Rossi Varallo F; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil., Régis Leira-Pereira L; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Farmacéuticas de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Sao Paulo, Brasil.
Jazyk:	English; Spanish; Castilian
Zdroj:	Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria [Farm Hosp] 2024 Nov-Dec; Vol. 48 (6), pp. T286-T289. Date of Electronic Publication: 2024 Jul 17.
DOI:	10.1016/j.farma.2024.05.014
Abstrakt:	Introduction: Intensive Care Units (ICUs) pose challenges in managing critically-ill patients with polypharmacy, potentially leading to Adverse Drug Reactions (ADRs), particularly in the elderly. Objective: To evaluate whether the severity and clinical prognosis scores used in ICUs correlate with the prediction of ADRs in aged patients admitted to an ICU. Methods: A cohort study was conducted in a Brazilian University Hospital ICU. APACHE II and SAPS 3 assessed clinical prognosis, while GerontoNet ADR Risk Score and BADRI evaluated ADR risk at ICU admission. Severity of the patients' clinical conditions was evaluated daily based on the SOFA score. Adverse Drug Reaction (ADR) screening was performed daily through the identification of ADR triggers. Results: 1295 triggers were identified (median 30 per patient, IQR = 28), with 15 suspected ADRs. No correlation was observed between patient severity and ADRs at admission (p=0.26), during hospitalization (p=0.91), or at follow-up (p=0.77). There was also no association between death and ADRs (p=0.28) or worse prognosis and ADRs (p>0.05). Higher BADRI scores correlated with more ADRs (p=0.001). Conclusions: The data suggest that employing the severity and clinical prognosis scores used in Intensive Care Units is not sufficient to direct active pharmacovigilance efforts, which are therefore indicated for critically ill patients. (Copyright © 2024 Sociedad Española de Farmacia Hospitalaria (S.E.F.H). Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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