mGlu2/3 receptor agonist (LY354740) in anxiety.
| Autor: | Schoepp DD; 128 Mill Creek Road, Ardmore, PA 19003, United States. Electronic address: darryle.schoepp@comcast.net. |
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| Jazyk: | angličtina |
| Zdroj: | Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2024 Sep; Vol. 242, pp. 173826. Date of Electronic Publication: 2024 Jul 18. |
| DOI: | 10.1016/j.pbb.2024.173826 |
| Abstrakt: | mGlu2/3 Receptors (LY354740) in Anxiety mGlu2/3 receptors when activated decrease glutamate excitation on limbic synapses involved in anxiety. The orally active agonist compound LY354740 (or prodrug LY544344) was active in animal and human models of stress/anxiety. Later clinical studies showed efficacy in generalized anxiety in patients, validating this mechanism clinically. However, the compound was terminated due to rodent seizures in long-term toxicology studies. (Copyright © 2024. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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