Altered brain and physiological stress responses in early psychosis.

Autor: Feola B; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, United States of America. Electronic address: brandee.feola@vumc.org., Flook EA; University of Pennsylvania Medical School, United States of America., Seo DJ; Yale School of Medicine, United States of America., Fox V; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, United States of America., Oler J; University of Miami School of Medicine, United States of America., Heckers S; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, United States of America., Woodward ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, United States of America., Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, United States of America.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Sep; Vol. 271, pp. 112-119. Date of Electronic Publication: 2024 Jul 17.
DOI: 10.1016/j.schres.2024.07.018
Abstrakt: Stress is proposed to be a crucial factor in the onset and presentation of psychosis. The early stage of psychosis provides a window into how stress interacts with the emergence of psychosis. Yet, how people with early psychosis respond to stress remains unclear. The current study examined how stress responses (brain, physiological, self-report) differ in early psychosis. Forty participants (20 early psychosis [EP], 20 healthy controls [HC]) completed a stress task in the scanner that involved viewing stressful and neutral-relaxing images. Physiological responses (cortisol, heart rate) and self-report of stress were also assessed. Region of Interest analyses were conducted with brain regions previously shown to be activated during the stress task (amygdala, hippocampus, striatum, hypothalamus, prefrontal cortex [dorsolateral, ventrolateral, medial orbital]). Linear mixed models were used to test for effects of group (EP, HC) and emotion (stress, neutral-relaxing). HC had higher hippocampus activation to stress versus neutral-relaxing conditions while EP did not show a difference (group x emotion interaction, p = 0.04). There were also significant main effects of group with EP having higher amygdala activation (p = 0.01), ventrolateral prefrontal cortex activation (vlPFC, p = 0.03), self-report of stress (p = 0.01), and heart rate (p < 0.001). Our study found preliminary evidence that people with early psychosis showed heightened response to stressful and non-threatening situations, across multiple levels of stress responses. Our findings suggest a novel perspective on stress alterations in early psychosis and highlight the importance of considering both stressful and non-stressful situations.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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