Polystyrene nanoplastics at predicted environmental concentrations enhance the toxicity of copper on Caenorhabditis elegans.

Autor: Zhu J; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China; Institute of Digital Ecology and Health, Huainan Normal University, Huainan, Anhui 232038, China. Electronic address: jczhu@hnnu.edu.cn., Miao G; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China; Institute of Digital Ecology and Health, Huainan Normal University, Huainan, Anhui 232038, China., Jiang H; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China., Su H; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China., Wang Y; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China., Chen L; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China., Zhang J; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China; Institute of Digital Ecology and Health, Huainan Normal University, Huainan, Anhui 232038, China., Wang Y; School of Bioengineering, Huainan Normal University, Huainan, Anhui 232038, China. Electronic address: yunwang2001@163.com.
Jazyk: angličtina
Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Sep 01; Vol. 282, pp. 116749. Date of Electronic Publication: 2024 Jul 17.
DOI: 10.1016/j.ecoenv.2024.116749
Abstrakt: Excessive nanoplastics not only pose a direct threat to the environment but also have the propensity to adsorb and interact with other pollutants, exacerbating their impact. The coexistence of nanoplastics and heavy metals in soils is a prevalent phenomenon. However, limited research existed about the joint effects of the two contaminants on soil organisms. In this paper, we ascertained the combined toxicity of polystyrene nanoplastics (PS-NPs) and copper (Cu 2+ ) on soil organisms (Caenorhabditis elegans) at quantities that were present in the environment, further exploring whether the two toxicants were synergistic or antagonistic. The outcomes manifested that single exposure to low-dose PS-NPs (1 μg/L) would not cause significant damage to nematodes. After treatment with PS-NPs and Cu 2+ , the locomotion ability of nematode was impaired, accompanied by an elevation in reactive oxygen species (ROS) level and a biphasic response in antioxidant enzyme activity. Moreover, combined exposure to PS-NPs and Cu 2+ induced the mRNA up-regulation of vit-6, cyp-35a2, hsp-16.2, age-1, and cep-1, both of which were stress-related genes. The comparative analysis between groups (with or without PS-NPs) revealed that the combined exposure group resulted in significantly greater toxic effects on nematodes compared with Cu 2+ exposure alone. Furthermore, the addition of PS-NPs influenced the metabolic profiles of Caenorhabditis elegans under Cu 2+ stress, with numerous differential metabolites associated with oxidative damage or defense mechanism. Overall, these findings manifested that PS-NPs at the expected environmental concentration elevated Cu 2+ toxicity on nematodes.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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