Solution studies, synthesis and antibacterial activity of Ga(III) complexes with bis-kojate derivatives.

Autor: O'Ferrall LM; Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland; School of Food Science & Environmental Health, Technological University of Dublin, Dublin 7, Ireland., Fantasia A; Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, via Vienna 2, 07100 Sassari, Italy; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy., Chan K; Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland., Teixeira LM; Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland., Kavanagh K; Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland; SSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, Ireland., O'Connor C; School of Food Science & Environmental Health, Technological University of Dublin, Dublin 7, Ireland., Santos MA; Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Insituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal., Chaves S; Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Insituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal., Nurchi VM; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy., Crisponi G; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy., Zoroddu MA; Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, via Vienna 2, 07100 Sassari, Italy., Griffith DM; Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland; SSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, Ireland. Electronic address: dgriffith@rcsi.ie., Cappai R; Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, via Vienna 2, 07100 Sassari, Italy. Electronic address: rcappai1@uniss.it.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Oct; Vol. 259, pp. 112663. Date of Electronic Publication: 2024 Jul 14.
DOI: 10.1016/j.jinorgbio.2024.112663
Abstrakt: Given the recognized major problem of microbial drug resistance for human health, new metal-based drugs have been currently explored for their antimicrobial properties, including gallium-based compounds as potential metallophores that could perturb Fe's interactions with proteins. Herein we have designed and synthesized two bis-kojate ligands (named L4 and L6) and studied their Ga(III) complexes for their physico-chemical and biological properties. In particular a detailed study of their complexation properties in aqueous solution, showed equilibrium models with formation of quite stable dinuclear 2:3 metal:ligand complexes, though with different stability. Solid state complexes were also prepared and characterized and complementary DFT studies indicated that [Ga 2 (L4) 3 ] complex, with higher stability, seems to adopt a three-ligand bridging conformation, while that for L6 adopt a one ligand bridging conformation. Preliminary investigation of the antibacterial activity of these gallium complexes showed antipseudomonal activity, which appeared higher for the complex with L4, a feature of potential interest for the scientific community.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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