The mechanics of tissue-engineered temporomandibular joint discs: Current status and prospects for enhancement.

Autor:	She Y; State Key Laboratory of Oral Diseases, and National Clinical Research Center for Oral Disease, and West China Hospital of Stomatology, Sichuan University, Chengdu, China., Sun Y; State Key Laboratory of Oral Diseases, and National Clinical Research Center for Oral Disease, and West China Hospital of Stomatology, Sichuan University, Chengdu, China., Jiang N; State Key Laboratory of Oral Diseases, and National Clinical Research Center for Oral Disease, and West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jazyk:	angličtina
Zdroj:	Journal of biomaterials applications [J Biomater Appl] 2024 Oct; Vol. 39 (4), pp. 269-287. Date of Electronic Publication: 2024 Jul 18.
DOI:	10.1177/08853282241265059
Abstrakt:	The temporomandibular joint (TMJ) disc is an essential protective but vulnerable fibrocartilage. Their high mechanical strength is vital in absorbing loads, reducing friction, and protecting the condylar surface. Many diseases can lead to the destruction or degeneration of the mechanical function of the TMJ disc. Unfortunately, conservative treatment is ineffective in restoring the defective mechanical properties of the discs. Tissue engineering has been investigated as a promising alternative treatment approach to approximate the properties of native tissue. However, it is difficult for tissue-engineered discs to obtain sufficient mechanical properties. Several approaches have been proposed to improve the mechanical properties of tissue-engineered constructs. In this review, we summarized the mechanical properties of native TMJ discs and discussed the current mechanical testing methods. We then summarized the current advances in improving the mechanical properties of TMJ disc tissue-engineered constructs. Moreover, existing challenges and outbreak directions are discussed. This review assists future research in better understanding the mechanical properties of both native and tissue-engineered TMJ discs. It provides new insights into future mechanical property enhancement for TMJ disc tissue engineering. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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