Study of Radiosensitivity and Induction of Radiation Adaptive Response in Peripheral Blood Lymphocytes of Patients with Oncological Diseases Using the Micronuclear Test.

Autor: Balakin VE; Physical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Moscow oblast, Russia., Rozanova OM; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia., Strelnikova NS; Physical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Moscow oblast, Russia. strelnikova.ns@lebedev.ru., Smirnova EN; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia., Belyakova TA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.; Logunov Institute for High Energy Physics, National Research Centre 'Kurchatov Institute', Protvino, Moscow oblast, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2024 Oct; Vol. 518 (1), pp. 355-360. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1134/S1607672924600362
Abstrakt: Radiosensitivity to low and medium doses of X-ray radiation and the ability to induce a radiation adaptive response (RAR) of lymphocytes during in vitro irradiation of peripheral blood of patients with cancer were studied. The criterion for cytogenetic damage was the frequency of micronuclei (MN) in cytochalasin-blocked binucleate lymphocytes in culture. It was found that the spontaneous level of cytogenetic damage in the lymphocytes of patients was 2.6 times higher than in healthy volunteers, and there was also significant interindividual variability in values compared to the control cohort. There were no differences in mean values for radiosensitivity to low and medium doses of X-ray between the study groups. There was no correlation between the spontaneous level of MN in lymphocytes and the radiosensitivity of individuals in both groups. RAR was induced with the same frequency and to the same extent in lymphocytes from both patients and healthy individuals.
(© 2024. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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