Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements.

Autor: Wyler F; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Manogaran T; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Monney N; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Salem Y; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Steinberg R; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Kentgens AC; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Graduate School for Health Sciences, University of Bern, Bern, Switzerland., Jacobs C; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa., Chaya S; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa., Sena CRDS; University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland., Künstle N; University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland., Gorlanova O; University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland., Yammine S; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Gray DM; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa., Frey U; University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland., Oestreich MA; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Latzin P; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1002/ppul.27180
Abstrakt: Introduction: Major methodological issues with the existing algorithm (WBreath) used for the analysis of speed-of-sound-based infant sulfur hexafluoride (SF 6 ) multiple-breath washout (MBW) measurements lead to implausible results and complicate the comparison between different age groups and centers.
Methods: We developed OASIS-a novel algorithm to analyze speed-of-sound-based infant SF 6 MBW measurements. This algorithm uses known context of the measurements to replace the dependence of WBreath on model input parameters. We validated the functional residual capacity (FRC) measurement accuracy of this new algorithm in vitro, and investigated its use in existing infant MBW data sets from different infant cohorts from Switzerland and South Africa.
Results: In vitro, OASIS managed to outperform WBreath at FRC measurement accuracy, lowering mean (SD) absolute error from 5.1 (3.2) % to 2.1 (1.6) % across volumes relevant for the infant age range, in variable temperature, respiratory rate, tidal volume and ventilation inhomogeneity conditions. We showed that changes in the input parameters to WBreath had a major impact on MBW results, a methodological drawback which does not exist in the new algorithm. OASIS produced more plausible results than WBreath in longitudinal tracking of lung clearance index (LCI), provided improved measurement stability in LCI over time, and improved comparability between centers.
Discussion: This new algorithm represents a meaningful advance in obtaining results from a legacy system of lung function measurement by allowing a single method to analyze measurements from different age groups and centers.
(© 2024 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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