A rare case of hidradenocarcinoma with anaplastic and invasive features arising from a nodulocystic hidradenoma.

Autor: McCrary MR; Anatomic and Clinical Pathology, USF Health Morsani College of Medicine, Tampa, Florida, USA., Beekman KE; USF Health Morsani College of Medicine, Tampa, Florida, USA., Strosberg C; Anatomic and Clinical Pathology, James A. Haley Veterans' Hospital, Tampa, Florida, USA., Turner L; Anatomic and Clinical Pathology, James A. Haley Veterans' Hospital, Tampa, Florida, USA., Sanik E; Department of Dermatology, James A. Haley Veterans Hospital, Tampa, Florida, USA., Beachkofsky TM; Department of Dermatology, James A. Haley Veterans Hospital, Tampa, Florida, USA.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2024 Dec; Vol. 51 (12), pp. 925-929. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1111/cup.14686
Abstrakt: A 91-year-old man presented with a cutaneous left abdominal mass. The mass was longstanding (over 5 years) and slow-growing. Examination revealed a violaceous, multinodular, and exophytic non-tender mass surrounded by patchy erythema. Excisional biopsy was performed and revealed a nodular and cystic dermal proliferation of predominately basaloid cells with focal duct formation, surrounded by prominent hyalinized stroma. The superficial portion of the mass was identified as a nodulocystic hidradenoma. Along the deep aspect and in association with the benign hidradenoma, sheets of markedly atypical epithelioid cells invaded the surrounding tissue, consistent with malignant transformation. Perineural and lymphovascular invasion were seen among areas with anaplastic features. This case supports that some hidradenocarcinoma originates from benign counterparts, and as such, ample sampling is required to definitively exclude a more sinister diagnosis. Diagnostic, prognostic, histopathological, and molecular characteristics, and current knowledge limitations are briefly discussed.
(Published 2024. This article is a U.S. Government work and is in the public domain in the USA.)
Databáze: MEDLINE
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