Acute hemorrhagic edema of infancy: 20-year experience from an Italian tertiary referral center.

Autor: Fiordelisi A; Residency School of Pediatrics, Department of Health Sciences, University of Florence, Firenze, Italy., Soldovieri S; Residency School of Pediatrics, Department of Health Sciences, University of Florence, Firenze, Italy., Pagnini I; Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Marrani E; Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Simonini G; Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.; NEUROFARBA Department, University of Florence, Firenze, Italy., Indolfi G; NEUROFARBA Department, University of Florence, Firenze, Italy.; Pediatric Unit, Meyer Children's Hospital IRCCS, Florence, Italy., Trapani S; Pediatric Unit, Meyer Children's Hospital IRCCS, Florence, Italy.; Department of Health Sciences, University of Florence, Florence, Italy.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2024 Sep-Oct; Vol. 41 (5), pp. 825-830. Date of Electronic Publication: 2024 Jul 18.
DOI: 10.1111/pde.15707
Abstrakt: Purpose: Data on acute hemorrhagic edema of infancy (AHEI) are derived from small case series or case reports. We report a 20-year experience at a national referral center.
Methods: We performed a single-center retrospective study including patients who were diagnosed with AHEI from January 1, 2004, to June 30, 2023.
Results: We identified 21 patients (57.1% females) with a median age of 18 months (range 7-33 months). Thirteen (61.9%) patients were admitted to the pediatric ward, the remaining eight (38.1%) presented to the emergency department and were discharged for outpatient management. The median length of hospitalization was 5 days (range 3-9 days). Twenty patients (95.2%) had prodromal symptoms. The most common cutaneous findings were targetoid purpuric plaques. The lesions were most localized on the face (13, 61.9%) and on the upper limbs (18 patients, 85.7%). Sixteen (76%) patients presented with nonpitting and tender edema, localized on the feet (9/16, 56%) and hands (6/16, 37.5%). Systemic involvement was rare, and no patients experienced complications or sequelae. Twelve (57.1%) patients underwent infectious disease investigations, with positive results in only four (33.3%). None of the patients diagnosed after the SARS-CoV-2 outbreak (March 2020) had positive nasopharyngeal swabs for the virus. For the 13 patients who were admitted to the pediatric ward, the median length of hospitalization was five days (3-9 days).
Conclusions: The 21-patient single-center cohort of children affected by AHEI confirmed a generally benign course of AHEI, despite a 62% rate of hospitalization.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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